Evidence map›Paper›PMID 34049438›Full record

ArticleThyroid : official journal of the American Thyroid Association2021

Measurement of Reverse Triiodothyronine Level and the Triiodothyronine to Reverse Triiodothyronine Ratio in Dried Blood Spot Samples at Birth May Facilitate Early Detection of Monocarboxylate Transporter 8 Deficiency.

Hideyuki Iwayama, Hiroki Kakita, Masumi Iwasa, Shinsuke Adachi, Kyoko Takano, Masahiro Kikuchi, Yasuko Fujisawa, Hitoshi Osaka, Yasumasa Yamada, Akihisa Okumura and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Thyroid : official journal of the American Thyroid Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Thyrotoxicosis in MCT8 deficiency.The Journal of clinical endocrinology and metabolism · 2026
    Review
  2. MCT8 Deficiency in Infancy: Opportunities for Early Diagnosis and Screening.International journal of neonatal screening · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Severe neurodevelopmental phenotype, diagnostic, and treatment challenges in patients with SECISBP2 deficiency.Genetics in medicine : official journal of the American College of Medical Genetics · 2024
    Article
  8. Article
  9. Article
  10. Diagnosis and Therapy in MCT8 Deficiency: Ongoing ChallengesJournal of clinical research in pediatric endocrinology · 2024
    Article
  11. Review
  12. Article
  13. Thyroid Hormone Transporters in Pregnancy and Fetal Development.International journal of molecular sciences · 2022
    Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

Hideyuki IwayamaDepartment of Pediatrics, School of Medicine, Aichi Medical University, Nagakute, Japan.
Hiroki KakitaDepartment of Perinatal and Neonatal Medicine, School of Medicine, Aichi Medical University, Nagakute, Japan.
Masumi IwasaDepartment of Pediatrics, School of Medicine, Aichi Medical University, Nagakute, Japan.
Shinsuke AdachiDepartment of Pediatrics, Fukuchiyama City Hospital, Kyoto, Japan.
Kyoko TakanoCenter for Medical Genetics, Shinshu University Hospital, Nagano, Japan.
Masahiro KikuchiDepartment of Pediatrics, Hitachi General Hospital, Hitachi, Japan.
Yasuko FujisawaDepartment of Pediatrics, School of Medicine, Hamamatsu University, Hamamatsu, Japan.
Hitoshi OsakaDepartment of Pediatrics, Jichi Medical School, Shimotsuke, Japan.
Yasumasa YamadaDepartment of Perinatal and Neonatal Medicine, School of Medicine, Aichi Medical University, Nagakute, Japan.
Akihisa OkumuraDepartment of Pediatrics, School of Medicine, Aichi Medical University, Nagakute, Japan.
Khemraj HiraniDepartment of Medicine, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Roy E WeissDepartment of Medicine, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Samuel RefetoffDepartments of Medicine, Pediatrics and Committee on Genetics, The University of Chicago, Chicago, Illinois, USA.ORCID 0000-0003-0164-8231
Aichi Medical University · JPUniversity of Miami · USFukuyama City Hospital · JPHamamatsu University · JPHitachi General Hospital · JPJichi Medical University · JPShinshu University Hospital · JPUniversity of Chicago · US

Funding

THYROID PHYSIOLOGY STUDIES OF INHERITED DISORDERSR01DK015070 · NIDDK · UNIVERSITY OF CHICAGO · PI ANTONIO C BIANCO, Alexandra Mihaela Dumitrescu · 1986 to 2026
$8.1M
NIDDK NIH HHS R01 DK015070
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Dried Blood Spot TestingMutationNeonatal ScreeningBiomarkersEarly DiagnosisFemaleGenetic Predisposition to DiseaseHumansInfant, NewbornMaleMonocarboxylic Acid TransportersMuscle HypotoniaMuscular AtrophyPhenotypePredictive Value of TestsRetrospective StudiesBiomarkersMonocarboxylic Acid TransportersSLC16A2 protein, humanSymportersTriiodothyronineTriiodothyronine, Reversedried blood spotLC-MS/MSMCT8 deficiencynewborn screeningreverse T3

Identifiers

PMID34049438
PMCPMC8558056
OpenAlexW3165055032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.