Evidence map›Paper›PMID 34049357›Full record

ArticleAIDS (London, England)2021

Cervical cancer incidence stratified by age in women with HIV compared with the general population in the United States, 2002-2016.

Elizabeth A Stier, Eric Engels, Marie-Josèphe Horner, William T Robinson, Baozhen Qiao, Jennifer Hayes, Rana Bayakly, Bridget J Anderson, Lou Gonsalves, Karen S Pawlish and 3 more

Open access · greenAbstract read
In one paragraph

Article in AIDS (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 2 countries.

Elizabeth A StierDepartment of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA.
Eric EngelsDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
Marie-Josèphe HornerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
William T RobinsonSTD/HIV/Hepatitis Program, Louisiana Office of Public Health, Louisiana State University Health Sciences Center School of Public Health, New Orleans, LA.
Baozhen QiaoNew York State Cancer Registry, New York State Department of Health, Albany, NY.
Jennifer HayesMaryland Cancer Registry, Maryland Department of Health, Baltimore, MD.
Rana BayaklyGeorgia Department of Health, Atlanta, GA.
Bridget J AndersonBureau of Communicable Disease Control, New York State Department of Health, Albany, NY.
Lou GonsalvesConnecticut Tumor Registry, Connecticut Department of Public Health, Hartford, CT.
Karen S PawlishCancer Epidemiology Services, New Jersey Department of Health, Trenton, NJ.
Diego ZavalaPuerto Rico Central Cancer Registry, Comprehensive Cancer Center, University of Puerto Rico, San Juan, PR.
Analise MonterossoHIV/STD/HCV Epidemiology and Surveillance Branch, Department of State Health Services, Austin, TX, USA.
Meredith S ShielsDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
Division of Cancer Epidemiology and GeneticsNew York State Department of Health · USBoston University · USConnecticut Department of Public Health · USGeorgia Department of Public Health · USLouisiana State University Health Sciences Center New Orleans · USMaryland Department of Health · USNational Cancer Institute · USNew Jersey Department of Health · USTexas Department of State Health Services · USUniversity of Puerto Rico System · PR

Funding

Consortium for Advancing Management and Prevention of Cancer in People with HIVUM1CA121947 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Joseph A. Sparano · 2015 to 2026
$253.7M
University of Southern CaliforniaU01CA121947 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ABOULAFIA, DAVID M · 2006 to 2014
$54.7M
GEORGIA COMPREHENSIVE CANCER CONTROL PROGRAMU58DP003875 · DP · GEORGIA DIVISION OF PUBLIC HEALTH · PI O'CONNOR, JEAN CATHERINE · 2012 to 2014
$15.9M
Studies of HIV infection and its contribution to the natural history and outcomeZIACP101235 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ENGELS, ERIC A · 2021 to 2025
$12.6M
NEW JERSEY CANCER PREVENTION & CONTROL PROGRAMU58DP003931 · DP · NEW JERSEY STATE DEPT/HEALTH/SENIOR SRVS · PI RODRIQUEZ, GLORIA · 2012 to 2014
$11.9M
National HIV Surveillance SystemU62PS004001 · PS · NEW JERSEY STATE DEPT/HEALTH/SENIOR SRVS · PI BOLDEN, BARBARA JEAN · 2013 to 2016
$8.9M
HIV/AIDS SURVEILLANCEU62PS001005 · PS · CONNECTICUT STATE DEPT OF PUBLIC HEALTH · PI ROOME, AARON · 2008 to 2012
$4.7M
Core and Incidence Surveillance for HIV in MichiganU62PS004011 · PS · MICHIGAN STATE DEPARTMENT OF HEALTH AND HUMAN SERVICES · PI MACOMBER, KATHRYN EMERY · 2013 to 2016
$3.7M
Prioritizing county-level social determinants that contribute to the greater burden of diabetes and hypertension in the USU01DP006302 · DP · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARSON, APRIL P · 2017 to 2021
$3.6M
NATIONAL HIV SURVEILLANCE SYSTEM (NHSS)U62PS003960 · PS · COLORADO STATE DEPT/PUB HLTH & ENVIRONMT · PI MATTSON, MELANIE · 2013 to 2016
$2.9M
ACL HHS U01DP006302NCCDPHP CDC HHS U01 DP006302NCCDPHP CDC HHS U58 DP003875NCCDPHP CDC HHS U58 DP003931NCHHSTP CDC HHS U62 PS001005NCHHSTP CDC HHS U62 PS003960NCHHSTP CDC HHS U62 PS004001NCHHSTP CDC HHS U62 PS004011NCI NIH HHS HHSN261201300021CNCI NIH HHS HHSN261201800002BNCI NIH HHS HHSN261201800002CNCI NIH HHS HHSN261201800007CNCI NIH HHS HHSN261201800009CNCI NIH HHS HHSN261201800009INCI NIH HHS U01 CA121947NCI NIH HHS UM1 CA121947
6 · The paper itself

Abstract

objectiveRecommendations for the age of initiating screening for cervical cancer in women with HIV (WWH) in the United States have not changed since 1995 when all women (regardless of immune status) were screened for cervical cancer from the age of onset of sexual activity, which often occurs in adolescence. By 2009, recognizing the lack of benefit as well as harms in screening young women, guidelines were revised to initiate cervical cancer screening for the general population at age 21 years. By comparing cervical cancer incidence in young WWH to that of the general population, we assessed the potential for increasing the recommended age of initiating cervical cancer screening in WWH.

designWe compared age-specific invasive cervical cancer (ICC) rates among WWH to the general population in the United States HIV/AIDS Cancer Match Study.

methodsWe estimated standardized incidence ratios as the observed number of cervical cancer cases among WWH divided by the expected number, standardized to the general population by age, race/ethnicity, registry, and calendar year.

resultsICC rates among WWH were elevated across all age groups between ages 25 and 54 years (SIR = 3.80; 95% CI 3.48--4.15) but there were zero cases among ages less than 25 years.

conclusionThe absence of ICC among WWH less than 25 years supports initiating cervical cancer screening at age 21 years, rather than adolescence, to prevent cancers in WWH at ages with higher risk of ICC.

Indexed as

HIV InfectionsUterine Cervical NeoplasmsAdolescentAdultEarly Detection of CancerFemaleHumansIncidenceMass ScreeningMiddle AgedUnited StatesYoung Adult

Identifiers

PMID34049357
PMCPMC8373779
OpenAlexW3165791280

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.