ArticleSleep medicine2021
Maturational trajectories of non-rapid eye movement slow wave activity and odds ratio product in a population-based sample of youth.
Article in Sleep medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Data-driven derivation of a multidimensional sleep health framework in adolescents.Sleep health · 2026Article
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- Evidence of how the maturing sleeping brain contributes to the sleepy brain of adolescents.Sleep · 2024Article
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- Edward O. Bixler, PhD: from the Apollo project and chimpanzees to sleep epidemiology.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Earlier Bedtime and Its Effect on Adolescent Sleep Duration.Pediatrics · 2023Article
- New insights and potential clinical implications of the odds ratio product.Frontiers in neurology · 2023Article
- The multidimensionality of sleep in population-based samples: a narrative review.Journal of sleep research · 2022Review
- Article
- Evidence of a maturational disruption in non-rapid eye movement sleep slow wave activity in youth with attention-deficit/hyperactivity, learning and internalizing disorders.Sleep medicine · 2022Article
- Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundBrain maturation is reflected in the sleep electroencephalogram (EEG) by a decline in non-rapid eye movement (NREM) slow wave activity (SWA) throughout adolescence and a related decrease in sleep depth. However, this trajectory and its sex and pubertal differences lack replication in population-based samples. We tested age-related changes in SWA (0.4-4 Hz) power and odds ratio product (ORP), a standardized measure of sleep depth.
methodsWe analyzed the sleep EEG of 572 subjects aged 6-21 y (48% female, 26% racial/ethnic minority) and 332 subjects 5-12 y followed-up at 12-22 y. Multivariable-adjusted analyses tested age-related cross-sectional and longitudinal trajectories of SWA and ORP.
resultsSWA remained stable from age 6 to 10, decreased between ages 11 and 17, and plateaued from age 18 to 21 (p-cubic<0.001); females showed a longitudinal decline 23% greater than males by 13 y, while males experienced a steeper slope after 14 y and their longitudinal decline was 21% greater by 19 y. More mature adolescents (75% female) experienced a greater longitudinal decline in SWA than less mature adolescents by 14 y. ORP showed an age-related increasing trajectory (p-linear<0.001) with no sex or pubertal differences.
conclusionsWe provide population-level evidence for the maturational decline and sex and pubertal differences in SWA in the transition from childhood to adolescence, while introducing ORP as a novel metric in youth. Along with previous studies, the distinct trajectories observed suggest that age-related changes in SWA reflect brain maturation and local/synaptic processes during this developmental period, while those of ORP may reflect global/state control of NREM sleep depth.
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