ArticleJournal of cardiac failure2021
Aortic Pulsatility Index: A Novel Hemodynamic Variable for Evaluation of Decompensated Heart Failure.
Article in Journal of cardiac failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Integrated Hemodynamic Measures of Cardiac Function and Association With Clinical Outcomes.JACC. Advances · 2026Article
- Advanced Markers for Hemodynamic Monitoring in Cardiogenic Shock and End-Stage Heart Failure: A Mini Review.Heart failure reviews · 2025Review
- Novel Hemodynamic Markers and Kidney Function in Patients with Acute Decompensated Heart Failure.Kidney360 · 2025Article
- Right Heart Catheterization in Patients With Advanced Heart Failure: Novel Hemodynamic Parameters for Risk Stratification.Korean circulation journal · 2025Article
- Low Aortic Pulsatility Index and Pulmonary Artery Pulsatility Index Are Associated With Increased Mortality in Patients With Dilated Cardiomyopathy Awaiting Heart Transplantation.Korean circulation journal · 2025Article
- Prognostic Significance of Hemodynamics in Patients With Transposition of the Great Arteries and Systemic Right Ventricle.Circulation. Heart failure · 2024Article
- Dynamic assessment of left ventricular coupling and myocardial reserve in patients with cardiogenic shock.European heart journal open · 2024Article
- Hemodynamic management of cardiogenic shock in the intensive care unit.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024Review
- PREDICT HF: Risk stratification in advanced heart failure using novel hemodynamic parameters.Clinical cardiology · 2024Article
- Improved Prognostic Performance of Right Atrial Pressure-Corrected Cardiac Power Output in Pulmonary Hypertension and Heart Failure with Preserved Ejection Fraction.Journal of cardiovascular translational research · 2024Article
- Observational
- Advanced hemodynamics for prognostication in heart failure: the pursuit of the patient-specific tipping point.Frontiers in cardiovascular medicine · 2024Article
- Cardiac mechanics and reverse remodelling under mechanical support from left ventricular assist devices.Frontiers in cardiovascular medicine · 2023Review
- Should We Be Using Aortic Pulsatility Index Over Cardiac Power Output in Heart Failure Cardiogenic Shock?Circulation. Heart failure · 2022Article
- Aortic Pulsatility Index: A New Haemodynamic Measure with Prognostic Value in Advanced Heart Failure.Cardiac failure review · 2022Review
- The prognostic utility of the pulmonary artery pulsatility and aortic pulsatility index in patients with heart failure: A systematic review.JRSM cardiovascular diseaseReview
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundRight heart catheterization for invasive hemodynamics has shown only modest correlation with clinical outcomes. We designed a novel hemodynamic variable that incorporates ventricular output and filling pressure. We anticipated that the aortic pulsatility index (API) would correlate with clinical outcomes in patients with heart failure. METHODS AND
resultsWe retrospectively analyzed consecutive patients undergoing right heart catheterization with milrinone drug study at our institution (February 2013 to November 2019). The API was calculated as (systolic blood pressure - diastolic blood pressure)/pulmonary capillary wedge pressure. The primary outcome was freedom from advanced therapies, defined as the need for inotropes, temporary mechanical circulatory support, a left ventricular assist device, or orthotopic heart transplantation, or death at 30 days. A total of 224 patient encounters, age 57 years (48-66 years; 34% women; 31% ischemic cardiomyopathy) were included. In univariable analysis, lower baseline API was significantly associated with progression to advanced therapies or death at 30-days (odds ratio 0.43, 95% confidence interval 0.30-0.61; P < .001) compared with those on continued medical management. Receiver operator characteristic analysis specified an optimal cutpoint of 1.45 for API. A Kaplan-Meier analysis indicated an association of API with the primary outcome (79% for API ≥ 1.45 vs 48% for API < 1.45). In multivariable analysis, higher API was strongly associated with freedom from advanced therapies or death (odds ratio 0.38, 95% confidence interval 0.22-0.65, P ≤ .001), even when adjusted for baseline characteristics and routine right heart catheterization measurements.
conclusionsThe API is a novel invasive hemodynamic measurement that is associated independently with freedom from advanced therapies or death at 30-day follow-up.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.