ReviewInternational journal of radiation oncology, biology, physics2021
Proton Therapy for Breast Cancer: A Consensus Statement From the Particle Therapy Cooperative Group Breast Cancer Subcommittee.
Review in International journal of radiation oncology, biology, physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The use of Hybrid Techniques in Whole-Breast Radiotherapy: A Systematic Review.Technology in cancer research & treatmentPooled it
- Conventional versus hypofractionated postmastectomy proton radiotherapy in the USA (MC1631): a randomised phase 2 trial.The Lancet. Oncology · 2023Trial
- Cardiac substructure dosimetry in thoracic radiotherapy: moving beyond mean heart dose and toward precision cardiac risk mitigation.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Review
- Necessity of energy layer repainting for proton radiotherapy in breast cancer patients.Physics and imaging in radiation oncology · 2026Article
- The global landscape of particle beam radiotherapy trials over the past 15 years.Cancer pathogenesis and therapy · 2026Article
- Risk of Radiation-Associated Contralateral Breast Cancer in Germline Mutation Carriers: A Meta-Analysis and Systematic Review.Cancers · 2026Review
- Breast cancer patients with ipsilateral diaphragm paralysis: practical breast radiotherapy using continuous positive airway pressure-assisted breathing to spare normal organs.Technical innovations & patient support in radiation oncology · 2026Article
- Poly ADP Ribose Polymerase Inhibitors Potentiate Proton Therapy End-of-Range Effects by Accelerating Replication Forks and Promoting Transcription Conflict.International journal of radiation oncology, biology, physics · 2026Article
- Toxicity profiles of proton and photon radiotherapy in postoperative breast cancer: a 10-year real-world cohort study.Breast cancer research : BCR · 2026Article
- Breast cancer radiotherapy and the risk of lung injury: Advances and perspectives.Advances in radiotherapy & nuclear medicine · 2026Article
- Cost-Effectiveness of Proton Therapy Compared With Photon Therapy in Breast Cancer.JAMA network open · 2026Article
- Knowledge-based planning for intensity-modulated proton therapy of the breast and chest wall with regional lymph nodes: development, validation, and comparative evaluation of two models.Frontiers in oncology · 2026Article
- Article
- Redefining cardiac risk in breast radiotherapy: a substructure-based dosimetric and biomarker correlation study.Cardio-oncology (London, England) · 2025Article
- Implementation of Proton Radiation Treatment Exclusion Volume Because of Inconsistent Location of Breast Expander Titanium Port.Advances in radiation oncology · 2025Article
- Bystander Effects in Osteoblasts and Osteoclasts: Comparison Between X- and Proton-Irradiation.International journal of particle therapy · 2025Article
- Assessment of Carrier-Free Metallacarboranes for Targeted Radiation Therapies PBFT and BNCT: Comparative Cellular Effects and Dosimetry Studies with [Pharmaceuticals (Basel, Switzerland) · 2025Article
- Postmastectomy Radiation Therapy: An ASTRO/ASCO/SSO Clinical Practice Guideline.Annals of surgical oncology · 2025Article
- Immediate 2-Stage breast reconstruction outcomes after proton or photon postmastectomy radiotherapy.Clinical and translational radiation oncology · 2025Article
- Towards proton therapy guidelines for radiation therapists and dosimetrists: A scoping review.Technical innovations & patient support in radiation oncology · 2025Review
3 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors.
Funding
Abstract
Radiation therapy plays an important role in the multidisciplinary management of breast cancer. Recent years have seen improvements in breast cancer survival and a greater appreciation of potential long-term morbidity associated with the dose and volume of irradiated organs. Proton therapy reduces the dose to nontarget structures while optimizing target coverage. However, there remain additional financial costs associated with proton therapy, despite reductions over time, and studies have yet to demonstrate that protons improve upon the treatment outcomes achieved with photon radiation therapy. There remains considerable heterogeneity in proton patient selection and techniques, and the rapid technological advances in the field have the potential to affect evidence evaluation, given the long latency period for breast cancer radiation therapy recurrence and late effects. In this consensus statement, we assess the data available to the radiation oncology community of proton therapy for breast cancer, provide expert consensus recommendations on indications and technique, and highlight ongoing trials' cost-effectiveness analyses and key areas for future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.