Evidence map›Paper›PMID 34048695›Full record

ReviewStem cell reports2021

ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts.

Insoo Hyun, Ellen Wright Clayton, Yali Cong, Misao Fujita, Steven A Goldman, Lori R Hill, Nuria Monserrat, Hiromitsu Nakauchi, Roger A Pedersen, Heather M Rooke and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Animus: human-embodied animals.Journal of medical ethics · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. New guidelines for embryo and stem cell research.Nature reviews. Molecular cell biology · 2021
    Article
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Insoo HyunDepartment of Bioethics, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Center for Bioethics, Harvard Medical School, Boston, MA, USA. Electronic address: insoo.hyun@case.edu.
Ellen Wright ClaytonCenter for Biomedical Ethics and Society, Departments of Pediatrics and Health Policy, Vanderbilt University Medical Center, Nashville, TN, USA; School of Law, Vanderbilt University, Nashville, TN, USA.
Yali CongDepartment of Medical Ethics and Law, Peking University School of Health Humanities, Beijing, China.
Misao FujitaUehiro Research Division for iPS Cell Ethics, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan; Institute for the Advanced Study of Human Biology, Kyoto University, Kyoto, Japan.
Steven A GoldmanUniversity of Rochester Medical Center, Rochester, NY, USA; University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark.
Lori R HillDepartment of Veterinary Medicine and Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Nuria MonserratPluripotency for Organ Regeneration. Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, Barcelona, Spain; Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Technology (BIST), 08028 Barcelona, Spain.
Hiromitsu NakauchiInstitute for Stem Cell Biology and Regenerative Medicine, Department of Genetics, Stanford University, Stanford, CA, USA; Division of Stem Cell Therapy, Institute of Medical Science University of Tokyo, Tokyo, Japan.
Roger A PedersenDepartment of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, USA.
Heather M RookeBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Jun TakahashiDepartment of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Jürgen A KnoblichInstitute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna, Austria; Medical University of Vienna, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The newly revised 2021 ISSCR Guidelines for Stem Cell Research and Clinical Translation includes scientific and ethical guidance for the transfer of human pluripotent stem cells and their direct derivatives into animal models. In this white paper, the ISSCR subcommittee that drafted these guidelines for research involving the use of nonhuman embryos and postnatal animals explains and summarizes their recommendations.

Indexed as

ChimeraPluripotent Stem CellsPractice Guidelines as TopicAnimalsEmbryo ResearchHumansSocieties, ScientificStem Cell ResearchStem Cell Transplantationanimal researchchimeric embryosISSCR guidelinesstem cell chimeras

Identifiers

PMID34048695
PMCPMC8190667

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.