Evidence map›Paper›PMID 34048692›Full record

ReviewStem cell reports2021

ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update.

Robin Lovell-Badge, Eric Anthony, Roger A Barker, Tania Bubela, Ali H Brivanlou, Melissa Carpenter, R Alta Charo, Amander Clark, Ellen Clayton, Yali Cong and 37 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 210 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
210citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

210 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. The Ethics of Human Embryo Editing via CRISPR-Cas9 Technology: A Systematic Review of Ethical Arguments, Reasons, and Concerns.HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues · 2025
    Pooled it
  2. Pooled it
  3. Human cardiovascular organoids: Biomedical applications and ethical challenges.American heart journal plus : cardiology research and practice · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Beyond Scar Removal: Reprogramming the Glial Scar for Neural Repair.International journal of molecular sciences · 2026
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. When to create embryos or organoids for research.Journal of medical ethics · 2026
    Article
  19. Article
  20. Review

150 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors.

Robin Lovell-BadgeFrancis Crick Institute, London, UK. Electronic address: robin.lovell-badge@crick.ac.uk.
Eric AnthonyInternational Society for Stem Cell Research, Skokie, IL, USA.
Roger A BarkerCambridge Center for Brain Repair and WT-MRC Stem Cell Institute, Cambridge, UK.
Tania BubelaSimon Fraser University, Burnaby, BC, Canada.
Ali H BrivanlouThe Rockefeller University, New York, NY, USA.
Melissa CarpenterElevateBio/Carpenter Group Consulting, Waltham, MA, USA.
R Alta CharoUniversity of Wisconsin-Madison, Madison, WI, USA.
Amander ClarkUniversity of California, Los Angeles, Los Angeles, CA, USA.
Ellen ClaytonVanderbilt University, Nashville, TN, USA.
Yali CongPeking University, Beijing, China.
George Q DaleyHarvard Medical School, Boston, MA, USA.
Jianping FuUniversity of Michigan, Ann Arbor, MI USA.
Misao FujitaKyoto University, Kyoto, Japan.
Andy GreenfieldMRC Harwell Institute, Oxfordshire, UK.
Steve A GoldmanUniversity of Rochester Medical Center, Rochester, NY, USA; University of Copenhagen, Copenhagen, Denmark.
Lori HillMD Anderson, Houston, TX, USA.
Insoo HyunHarvard Medical School, Boston, MA, USA; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Rosario IsasiUniversity of Miami, Coral Gables, FL, USA.
Jeffrey KahnBerman Institute of Bioethics, Johns Hopkins University, Baltimore, MD, USA.
Kazuto KatoOsaka University, Suita, Japan.
Jin-Soo KimSeoul National University, Seoul, Korea.
Jonathan KimmelmanMcGill University, Montreal, QC, Canada.
Jürgen A KnoblichIMBA-Institute of Molecular Biotechnology, Vienna, Austria.
Debra MathewsBerman Institute of Bioethics, Johns Hopkins University, Baltimore, MD, USA.
Nuria MontserratInstitute for Bioengineering of Catalonia (IBEC), Barcelona, Spain.
Jack MosherInternational Society for Stem Cell Research, Skokie, IL, USA.
Megan MunsieUniversity of Melbourne, Melbourne, VIC, Australia.
Hiromitsu NakauchiStanford University, Stanford, CA, USA; University of Tokyo, Tokyo, Japan.
Luigi NaldiniUniversità Vita-Salute San Raffaele, Milan, Italy.
Gail NaughtonHistogen, San Diego, CA, USA.
Kathy NiakanFrancis Crick Institute, London, UK; Centre for Trophoblast Research, University of Cambridge, Cambridge, UK.
Ubaka OgboguUniversity of Alberta, Edmonton, AB, Canada.
Roger PedersenStanford University, Stanford, CA, USA.
Nicolas RivronIMBA-Institute of Molecular Biotechnology, Vienna, Austria.
Heather RookeBroad Institute, Cambridge, MA, USA.
Janet RossantGairdner Foundation/SickKids, Toronto, ON, Canada.
Jeff RoundInstitute of Health Economics, Edmonton, AB, Canada.
Mitinori SaitouKyoto University, Kyoto, Japan.
Douglas SippRIKEN Center for Developmental Biology, Wako, Japan; Keio University School of Medicine, Tokyo, Japan.
Julie SteffannUniversité Paris Descartes, Paris, France.
Jeremy SugarmanBerman Institute of Bioethics, Johns Hopkins University, Baltimore, MD, USA.
Azim SuraniGurdon Institute, University of Cambridge, Cambridge, UK.
Jun TakahashiKyoto University, Kyoto, Japan.
Fuchou TangPeking University, Beijing, China.
Leigh TurnerUniversity of Minnesota, Minneapolis, MN, USA.
Patricia J ZettlerOhio State University, Columbus, OH, USA.
Xiaomei ZhaiPeking Union Medical College, Beijing, China.

Funding

Medical Research Council MC_PC_17230Medical Research Council MC_U142684167
6 · The paper itself

Abstract

The International Society for Stem Cell Research has updated its Guidelines for Stem Cell Research and Clinical Translation in order to address advances in stem cell science and other relevant fields, together with the associated ethical, social, and policy issues that have arisen since the last update in 2016. While growing to encompass the evolving science, clinical applications of stem cells, and the increasingly complex implications of stem cell research for society, the basic principles underlying the Guidelines remain unchanged, and they will continue to serve as the standard for the field and as a resource for scientists, regulators, funders, physicians, and members of the public, including patients. A summary of the key updates and issues is presented here.

Indexed as

PolicyPractice Guidelines as TopicStem CellsBioethical IssuesHumansSocieties, ScientificStem Cell Research

Identifiers

PMID34048692
PMCPMC8190668

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.