ReviewStem cell reports2021
Human embryo research, stem cell-derived embryo models and in vitro gametogenesis: Considerations leading to the revised ISSCR guidelines.
Review in Stem cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ethical, legal, regulatory, and policy issues concerning embryoids: a systematic review of the literature.Stem cell research & therapy · 2023Pooled it
- What counts as an embryo? : The regulatory status of stem cell-based embryo models in Asia.EMBO reports · 2026Article
- Human stem cell-based embryo models: innovation, ethics, and policy.Human reproduction (Oxford, England) · 2026Article
- Synthetic embryos: current progress, application and challenges.Reproductive biology and endocrinology : RB&E · 2026Review
- Considerations for the future of in vitro gametogenesis in fertility care.Nature biotechnology · 2026Article
- Primate embryoid models: functional interrogation of late gastrulation.Signal transduction and targeted therapy · 2026Article
- Implications for IVF if in vitro gametogenesis in humans were to become reality.Journal of assisted reproduction and genetics · 2026Article
- Stem cell-based therapies for silicosis: mechanisms, sources, clinical translation, and emerging strategies.Frontiers in immunology · 2026Review
- Stem cell-derived gametes: what to expect when expecting their clinical introduction.Human reproduction (Oxford, England) · 2025Review
- Stem cell-based human embryo models: current knowledge and open questions.Stem cell research & therapy · 2025Review
- Single Cell RNA Sequencing and Its Impact on Understanding Human Embryo Development.International journal of molecular sciences · 2025Review
- Making and disposing of life's 'starting materials': A focus group study of attitudes concerning reproductive scarcity and abundance in in vitro gametogenesis.Social science & medicine (1982) · 2025Article
- Three-Dimensional Models of Implantation Using Human Stem Cells: Scientific Insights and Broader Considerations.Biomolecules · 2025Review
- Stem cell-based embryo models: The 2021 ISSCR stem cell guidelines revisited.Stem cell reports · 2025Review
- Articulating the need to minimize moral incursions in research : The least infringement condition.EMBO reports · 2025Article
- Language and labels from the lab: Definitions in the stem cell-based embryo model debate.Stem cell reports · 2025Article
- Challenging the Astral mass analyzer to quantify up to 5,300 proteins per single cell at unseen accuracy to uncover cellular heterogeneity.Nature methods · 2025Article
- The paradoxical role of stem cells in osteosarcoma: from pathogenesis to therapeutic breakthroughs.Frontiers in oncology · 2025Review
- Article
- Early human development and stem cell-based human embryo models.Cell stem cell · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
The ISSCR Guidelines for Stem Cell Research and Clinical Translation were last revised in 2016. Since then, rapid progress has been made in research areas related to in vitro culture of human embryos, creation of stem cell-based embryo models, and in vitro gametogenesis. Therefore, a working group of international experts was convened to review the oversight process and provide an update to the guidelines. This report captures the discussion and summarizes the major recommendations made by this working group, with a specific emphasis on updating the categories of review and engagement with the specialized scientific and ethical oversight process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.