ArticlePLoS computational biology2021
Targeted modification of the Per2 clock gene alters circadian function in mPer2luciferase (mPer2Luc) mice.
Article in PLoS computational biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Advances in monitoring mammalian circadian components and their rhythms using reporter systems.RSC chemical biology · 2026Review
- Circadian Behavioral and Bioluminescence Rhythms in theJournal of biological rhythms · 2026Article
- Anti-skin aging effects of black ginseng extracts through regulating inflammatory factors and the CLOCK-ERK pathway in mice.Journal of ginseng research · 2026Article
- Chemical biology approaches to study and target circadian clocks and their components.FEBS letters · 2026Review
- Differential effects of sex and age on daily and infradian rhythms of mice.The Journal of physiology · 2026Article
- Effects of DNA methylation inhibitors on light-induced circadian clock plasticity.Neurobiology of sleep and circadian rhythms · 2025Article
- Feeding regime synchronizes circadian clock in choroid plexus - insight into a complex mechanism.Cellular and molecular life sciences : CMLS · 2025Article
- Circadian Rhythms in Murine Ocular Tissues Including Sclera Are Affected by Neurobasal A Medium Preincubation and Mouse Strain, but Not Sex.Investigative ophthalmology & visual science · 2025Article
- The Effects of Constant Light and Running-Wheel Access in Middle-Aged Female C57BL6/J Mice.Sleep science (Sao Paulo, Brazil) · 2025Article
- Biological Sex Influences Daily Locomotor Rhythms in Mice Held Under Different Housing Conditions.Journal of biological rhythms · 2024Article
- Mistimed restricted feeding disrupts circadian rhythms of male mating behavior and female preovulatory LH surges in mice.Hormones and behavior · 2022Article
- Cell-Type-Specific Circadian Bioluminescence Rhythms inJournal of biological rhythms · 2022Article
- Article
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
Abstract
Modification of the Per2 clock gene in mPer2Luc reporter mice significantly alters circadian function. Behavioral period in constant dark is lengthened, and dissociates into two distinct components in constant light. Rhythms exhibit increased bimodality, enhanced phase resetting to light pulses, and altered entrainment to scheduled feeding. Mechanistic mathematical modelling predicts that enhanced protein interactions with the modified mPER2 C-terminus, combined with differential clock regulation among SCN subregions, can account for effects on circadian behavior via increased Per2 transcript and protein stability. PER2::LUC produces greater suppression of CLOCK:BMAL1 E-box activity than PER2. mPer2Luc carries a 72 bp deletion in exon 23 of Per2, and retains a neomycin resistance cassette that affects rhythm amplitude but not period. The results show that mPer2Luc acts as a circadian clock mutation illustrating a need for detailed assessment of potential impacts of c-terminal tags in genetically modified animal models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.