Evidence map›Paper›PMID 34048308›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2022

Validation of an obstructive sleep apnea symptom inventory in persons with multiple sclerosis.

Mini Singh, Ronald Gavidia, Galit Levi Dunietz, Elizabeth Washnock-Schmid, Andrew R Romeo, Shelley Hershner, Ronald D Chervin, Tiffany J Braley

Open access · greenAbstract read
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
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  5. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mini SinghDepartment of Neurology, Medical University of South Carolina, Charleston, SC, USA.
Ronald GavidiaDivision of Sleep Medicine, Department of Neurology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-2090-693X
Galit Levi DunietzDivision of Sleep Medicine, Department of Neurology, University of Michigan, Ann Arbor, MI, USA.
Elizabeth Washnock-SchmidDivision of Multiple Sclerosis and Clinical Neuroimmunology, Department of Neurology, University of Michigan, Ann Arbor, MI, USA/VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
Andrew R RomeoDivision of Multiple Sclerosis and Clinical Neuroimmunology, Department of Neurology, University of Michigan, Ann Arbor, MI, USA/VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
Shelley HershnerDivision of Sleep Medicine, Department of Neurology, University of Michigan, Ann Arbor, MI, USA.
Ronald D ChervinDivision of Sleep Medicine, Department of Neurology, University of Michigan, Ann Arbor, MI, USA.
Tiffany J BraleyDivisions of Multiple Sclerosis, Clinical Neuroimmunology and Sleep Medicine, Department of Neurology, University of Michigan, Ann Arbor, MI, USA/Division of Multiple Sclerosis and Clinical Neuroimmunology, Department of Neurology, University of Michigan, Ann Arbor, MI, USA/VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.ORCID 0000-0003-0680-7828
University of Michigan · USMedical University of South Carolina · US

Funding

TRAINING IN CLINICAL AND BASIC NEUROSCIENCET32NS007222 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Henry L Paulson · 1985 to 2026
$8.0M
Associations of Sleep Duration and Dynamics with Biomarkers of Cardiometabolic Diseases; A micro-longitudinal ApproachK01HL144914 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DUNIETZ, GALIT LEVI · 2019 to 2023
$537k
NHLBI NIH HHS K01 HL144914NINDS NIH HHS T32 NS007222
6 · The paper itself

Abstract

backgroundImproved screening for obstructive sleep apnea (OSA) could enhance multiple sclerosis (MS) clinical care; yet the utility of current screening tools for OSA have yet to be evaluated in persons with multiple sclerosis (PwMS).

objectivesThe STOP-Bang Questionnnaire is an 8-item screening tool for OSA that is commonly used in non-MS samples. The aim of this study was to assess the validity of the STOP-Bang in PwMS.

methodsSTOP-Bang and polysomnography data were analyzed from

resultsNearly 70% had a STOP-Bang score of ⩾3% and 78% had OSA. The STOP-Bang at a threshold score of 3 provided sensitivities of 87% and 91% to detect moderate and severe OSA, respectively; and NPV of 84% and 95% to identify PwMS without moderate or severe OSA, respectively. Sensitivity to detect milder forms of OSA was 76%. The NPV to identify persons without milder forms of OSA was 40%.

conclusionThe STOP-Bang Questionnaire is an effective tool to screen for moderate and severe OSA in PwMS, but may be insufficient to exclude mild OSA.

Indexed as

Multiple SclerosisSleep Apnea, ObstructiveHumansMass ScreeningPolysomnographySurveys and QuestionnairesbrainstemfatigueMultiple sclerosisobstructive sleep apneasleepinessSTOP-Bang

Identifiers

PMID34048308
PMCPMC8627523
OpenAlexW3164675965

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.