Evidence map›Paper›PMID 34048174›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2021

Expressions of P-Glycoprotein, Multidrug Resistance Protein 1 and Annexin A2 as Predictive Factors for Intravesical Recurrence of Bladder Cancer after the Initial Transurethral Resection and Immediate Single Intravesical Instillation of Adriamycin.

Harutake Sawazaki, Keiichi Ito, Takako Asano, Kenji Kuroda, Akio Horiguchi, Hitoshi Tsuda, Tomohiko Asano

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Harutake SawazakiDepartment of Urology, National Defense Medical College Tokorozawa, Japan.
Keiichi ItoDepartment of Urology, National Defense Medical College Tokorozawa, Japan.
Takako AsanoDepartment of Urology, National Defense Medical College Tokorozawa, Japan.
Kenji KurodaDepartment of Urology, National Defense Medical College Tokorozawa, Japan.
Akio HoriguchiDepartment of Urology, National Defense Medical College Tokorozawa, Japan.
Hitoshi TsudaDepartment of Basic Pathology, National Defense Medical College Tokorozawa, Japan.
Tomohiko AsanoDepartment of Urology, National Defense Medical College Tokorozawa, Japan.
National Defense Medical College Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveImmediate single instillation of chemotherapy following transurethral resection of bladder tumor (TURBT) is suggested for non-muscle invasive bladder cancer (NMIBC) patients. However, no study has evaluated molecular marker that was involved in intravesical recurrence (IVR) after single instillation of chemotherapy. Therefore, this study aimed to evaluate whether P-glycoprotein, multidrug resistance protein 1 (MRP1), Annexin A2 (ANXA2) or nucleophosmin (NPM) expression predicts IVR after initial TURBT and immediate single intravesical adriamycin instillation.

methodsWe retrospectively reviewed consecutive 443 patients who underwent TURBT. Of these, 54 patients who underwent initial TURBT and single instillation of adriamycin for NMIBC were included. The expressions of P-glycoprotein, MRP1, ANXA2 and NPM were evaluated immunohistochemically and were divided into 2 groups (low or high) according to the staining intensity and/or proportion of positive cells. IVR was assessed by Kaplan-Meier method. Cox`s multivaritate analyses were performed to identify independent predictors for IVR.

resultsNineteen patients (35.1%) had IVR. High P-glycoprotein expression was significantly correlated with multiplicity, pT stage and high grade. High ANXA2 expression was significantly correlated with high grade. MRP1 and NPM were not correlated with any clinicopathological variables. MRP1 expression and ANXA2 expression were significantly correlated with P-glycoprotein expression. Patients with high P-glycoprotein expression had significantly worse IVR-free survival (IVRFS) than those with low P-glycoprotein expression (P =0.015). The difference in IVRFS rates between patients with high ANXA2 expression and those with low ANXA2 expression was nearly significant (P =0.057). Univariate analyses indicated multiplicity, high grade and high P-glycoprotein expression were significant predictors for IVR. Multivariate analysis indicated high grade was an independent predictor for IVR.

conclusionsHigh P-glycoprotein expression was associated with IVR. Further study was needed to determine significance of P-glycoprotein expression in IVR after single intravesical adriamycin instillation.

Indexed as

AgedAnnexin A2Antibiotics, AntineoplasticATP-Binding Cassette, Sub-Family C ProteinsATP Binding Cassette Transporter, Subfamily BBiomarkers, TumorCombined Modality TherapyCystectomyDoxorubicinFemaleFollow-Up StudiesHumansMaleNeoplasm Recurrence, LocalNuclear ProteinsNucleophosminABCB1 protein, humanAnnexin A2Antibiotics, AntineoplasticANXA2 protein, humanATP-Binding Cassette, Sub-Family C ProteinsATP Binding Cassette Transporter, Subfamily BBiomarkers, TumorDoxorubicinmultidrug resistance-associated protein 1NPM1 protein, humanNuclear ProteinsNucleophosminadriamycinbladder cancerintravesical recurrencep-glycoprotein

Identifiers

PMID34048174
PMCPMC8408374
OpenAlexW3164589909

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.