Evidence map›Paper›PMID 34048020›Full record

ReviewMethods in molecular biology (Clifton, N.J.)2021

Analgesia and Humane Endpoints for Rodents in Sepsis Research.

Christine A Boehm, Jean A Nemzek

Abstract readReview
PubMed Publisher
In one paragraph

Review in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
4.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Christine A BoehmLaboratory Animal Research Center, Texas Tech University Health Sciences Center at El Paso, El Paso, TX, USA. boehmec@gmail.com.
Jean A NemzekUnit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI, USA.
Texas Tech University Health Sciences Center · USUniversity of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous regulatory bodies around the world require analgesics for rodents undergoing surgery to induce sepsis. Well-controlled pain will decrease morbidity. Options for analgesics include NSAIDs, local analgesics, and opioids. Supportive care can also decrease stress to post-operative animals. As well, humane endpoints should be agreed upon before the study commences so as to alleviate unnecessary pain and distress.

Indexed as

AnalgesiaAnalgesics, OpioidAnimalsAnti-Inflammatory Agents, Non-SteroidalDisease Models, AnimalHumansPainPain ManagementRodentiaSepsisAnalgesics, OpioidAnti-Inflammatory Agents, Non-SteroidalAnalgesiaCecal ligation and punctureCecal slurryColon ascendens stent peritonitis and fibrin clot implantationHumane endpointsMouseSepsis

Identifiers

PMID34048020
OpenAlexW3165585311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.