Evidence map›Paper›PMID 34048010›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2021

A Mouse Model of Necrotizing Enterocolitis.

Belgacem Mihi, Wyatt E Lanik, Qingqing Gong, Misty Good

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Inhibition of IP6K1 suppresses NPA formation via platelet short-chain polyphosphate polymers in necrotizing enterocolitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Necrotizing Enterocolitis: What's New and What's Next?International journal of molecular sciences · 2025
    Review
  10. Article
  11. Article
  12. Paneth cell ontogeny in term and preterm ovine models.Frontiers in veterinary science · 2024
    Article
  13. Observational
  14. Article
  15. State-of-the-art review and update ofFrontiers in pediatrics · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Belgacem Mihi *Division of Newborn Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO, USA.
Wyatt E Lanik *Division of Newborn Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO, USA.
Qingqing Gong *Division of Newborn Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO, USA.
Misty GoodDivision of Newborn Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO, USA. mistygood@wustl.edu.

Funding

Modulation of the Intestinal Immune Response in Necrotizing EnterocolitisR01DK118568 · NIDDK · WASHINGTON UNIVERSITY · PI GOOD, MISTY L · 2018 to 2022
$1.8M
Novel Anti-Inflammatory Properties of Breast Milk in Necrotizing EnterocolitisK08DK101608 · NIDDK · WASHINGTON UNIVERSITY · PI GOOD, MISTY L · 2014 to 2017
$584k
Aryl hydrocarbon receptor signaling in the pathogenesis of necrotizing enterocolitisR03DK111473 · NIDDK · WASHINGTON UNIVERSITY · PI GOOD, MISTY L · 2017 to 2018
$153k
NIDDK NIH HHS K08 DK101608NIDDK NIH HHS R01 DK118568NIDDK NIH HHS R03 DK111473
6 · The paper itself

Abstract

Necrotizing enterocolitis (NEC) is an acute inflammatory disease that unforeseeably develops in very low birth weight premature infants. NEC is characterized by impairment of the intestinal barrier resulting in intestinal necrosis and multisystem organ failure. Animal models of NEC have contributed significantly to a better understanding of the underlying molecular mechanisms of the disease and facilitated the exploration of potential new therapeutic strategies. Here, we provide a detailed protocol that recapitulates some of the main histological and transcriptional features of human NEC in newborn mice.

Indexed as

AnimalsAnimals, NewbornDisease Models, AnimalEnterocolitis, NecrotizingHumansInfant, NewbornInfant, Newborn, DiseasesInflammationIntestinal MucosaIntestinesMiceMice, Inbred C57BLPremature BirthTranscription, GeneticEnteric bacteriaIntestinal inflammationMucosal barrierNecrotizing enterocolitisNeonatal mice

Identifiers

PMID34048010
PMCPMC8272439

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.