Evidence map›Paper›PMID 34048006›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2021

Injection of Escherichia coli to Induce Sepsis.

Xian-Hui He, Dong-Yun Ouyang, Li-Hui Xu

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  4. Review
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  6. Review
  7. Article
  8. Article
  9. B-1a cells scavenge NETs to attenuate sepsis.Journal of leukocyte biology · 2024
    Article
  10. Article
  11. Mouse Models of Sepsis.Current protocols · 2024
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Xian-Hui HeDepartment of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou, China. thexh@jnu.edu.cn.
Dong-Yun OuyangDepartment of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou, China.
Li-Hui XuDepartment of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China.
Jinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mouse models of bacterial sepsis are widely used in research to investigate the underlying molecular mechanisms of sepsis and to develop clinically useful therapeutic regimens. Three commonly used mouse sepsis models include (a) injection of bacterial endotoxin, (b) infusion of cultured bacteria, and (c) cecal ligation and puncture. Here we describe the induction of bacterial sepsis in mice by intraperitoneal injection of cultured live Escherichia coli cells. The severity of the sepsis can be regulated by the number of E. coli cells injected into the peritoneal cavity of mice.

Indexed as

AnimalsCecumDisease Models, AnimalEndotoxinsEscherichia coliInjections, IntraperitonealLigationMiceMice, Inbred C57BLPeritoneal CavityPuncturesSepsisEndotoxinsBacterial sepsisColony-forming unitsEscherichia coliInterleukin-1βIntraperitoneal injectionSurvival curveTissue damage

Identifiers

PMID34048006
OpenAlexW3164818021

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.