ArticleBiomechanics and modeling in mechanobiology2021
Bone morphogenetic protein 2-induced cellular chemotaxis drives tissue patterning during critical-sized bone defect healing: an in silico study.
Article in Biomechanics and modeling in mechanobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- From pixels to precision: a narrative review of AI-driven 3D morphological analysis and digital twinning in alveolar cleft management.Translational pediatrics · 2026Review
- Callus formation during healing is guided by local strain: a retrospective clinical observation.BMC musculoskeletal disorders · 2026Observational
- Computational models for predicting bone fracture healing: a review of modeling approaches, predictions, and emerging strategies.Biomechanics and modeling in mechanobiology · 2026Review
- Development of a subject-specific finite element analysis workflow to assess local biomechanics during segmental bone defect healing.Journal of the mechanical behavior of biomedical materials · 2025Article
- Moderate-Affinity Affibodies Modulate the Delivery and Bioactivity of Bone Morphogenetic Protein-2.Advanced healthcare materials · 2023Article
- Trabecular bone remodeling in the aging mouse: A micro-multiphysics agent-basedFrontiers in bioengineering and biotechnology · 2023Article
- COMMBINI: an experimentally-informed COmputational Model of Macrophage dynamics in the Bone INjury Immunoresponse.Frontiers in immunology · 2023Article
- AnFrontiers in bioengineering and biotechnology · 2023Article
- α-Hemihydrate calcium sulfate/n-hydroxyapatite combined with metformin promotes osteogenesisFrontiers in bioengineering and biotechnology · 2022Article
- PCL strut-like scaffolds appear superior to gyroid in terms of bone regeneration within a long bone large defect: AnFrontiers in bioengineering and biotechnology · 2022Article
- Calcium-Silicate-Incorporated Gellan-Chitosan Induced Osteogenic Differentiation in Mesenchymal Stromal Cells.Polymers · 2021Article
- TowardsFrontiers in bioengineering and biotechnology · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Critical-sized bone defects are critical healing conditions that, if left untreated, often lead to non-unions. To reduce the risk, critical-sized bone defects are often treated with recombinant human BMP-2. Although enhanced bone tissue formation is observed when BMP-2 is administered locally to the defect, spatial and temporal distribution of callus tissue often differs from that found during regular bone healing or in defects treated differently. How this altered tissue patterning due to BMP-2 treatment is linked to mechano-biological principles at the cellular scale remains largely unknown. In this study, the mechano-biological regulation of BMP-2-treated critical-sized bone defect healing was investigated using a multiphysics multiscale in silico approach. Finite element and agent-based modeling techniques were combined to simulate healing within a critical-sized bone defect (5 mm) in a rat femur. Computer model predictions were compared to in vivo microCT data outcome of bone tissue patterning at 2, 4, and 6 weeks postoperation. In vivo, BMP-2 treatment led to complete healing through periosteal bone bridging already after 2 weeks postoperation. Computer model simulations showed that the BMP-2 specific tissue patterning can be explained by the migration of mesenchymal stromal cells to regions with a specific concentration of BMP-2 (chemotaxis). This study shows how computational modeling can help us to further understand the mechanisms behind treatment effects on compromised healing conditions as well as to optimize future treatment strategies.
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Registered trials
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