Evidence map›Paper›PMID 34047871›Full record

ArticleClinical and experimental nephrology2021

Clinical and histological features in pediatric and adolescent/young adult patients with renal disease: a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR).

Maki Urushihara, Hiroshi Sato, Akira Shimizu, Hitoshi Sugiyama, Hitoshi Yokoyama, Hiroshi Hataya, Kentaro Matsuoka, Takayuki Okamoto, Daisuke Ogino, Kenichiro Miura and 9 more

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Article in Clinical and experimental nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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0cells of the map it votes in
5citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Maki UrushiharaDepartment of Pediatrics, Institute of Biomedical Sciences, Tokushima University Graduate School, Kuramoto-cho 3-18-15, Tokushima, Tokushima, 770-8503, Japan. urushihara@tokushima-u.ac.jp.ORCID http://orcid.org/0000-0002-6431-3239
Hiroshi SatoDeparment of Internal Medicine, Sendai Hospital of East Japan Railway Company, Sendai, Japan.
Akira ShimizuDepartment of Analytic Human Pathology, Nippon Medical School, Tokyo, Japan.
Hitoshi SugiyamaDepartment of Human Resource Development of Dialysis Therapy for Kidney Disease, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Hitoshi YokoyamaDepartment of Nephrology, Kanazawa Medical University, Uchinada, Japan.
Hiroshi HatayaDepartment of Nephrology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Kentaro MatsuokaDepartment of Pathology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Takayuki OkamotoDepartment of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Daisuke OginoDepartment of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.
Kenichiro MiuraDepatment of Pediatric Nephrology, School of Medicine, Tokyo Women's Medical University, Tokyo, Japan.
Riku HamadaDepartment of Nephrology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Satoshi HibinoDepartment of Pediatric Nephrology, Aichi Children's Health and Medical Center, Obu, Japan.
Yuko ShimaDepartment of Pediatrics, Wakayama Medical University, Wakayama City, Wakayama, Japan.
Tomohiko YamamuraDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Koichi KitamotoDivision of Pediatrics and Perinatology, Faculty of Medicine, Tottori University, Yonago, Japan.
Masayuki IshiharaDepartment of Pediatrics, Kochi Medical School, Kochi University, Kochi, Japan.
Takao KonomotoDivision of Pediatrics, Department of Reproductive and Developmental Medicine Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Motoshi HattoriDepatment of Pediatric Nephrology, School of Medicine, Tokyo Women's Medical University, Tokyo, Japan.
the Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOnly a few studies have investigated epidemiological and clinicopathological information regarding pediatric and adolescent and young adult (AYA) patients with renal disease. The purpose of this study was to clarify the differences and relationship of clinicopathological findings between pediatric and AYA patients using the Japan Renal Biopsy Registry (J-RBR).

methodsThis cross-sectional study analyzed data from patients registered in the J-RBR between 2007 and 2017. Clinicopathological findings at diagnosis were analyzed for 3,463 pediatric (age < 15 years) and 6,532 AYA (age 15-30 years) patients.

resultsAlthough chronic nephritic syndrome was the most common clinical diagnosis at age > 5 years, nephrotic syndrome was the most frequent diagnosis at age < 4 years. The most common pathological diagnosis as classified by pathogenesis in pediatric patients was primary glomerular disease (except IgA nephropathy), whereas IgA nephropathy was increased in AYA patients. Mesangial proliferative glomerulonephritis was the most common pathological diagnosis as classified by histopathology in both pediatric and AYA patients. Minor glomerular abnormalities were the most frequent histopathologic diagnoses of nephrotic syndrome in childhood, but their frequency decreased with age.

conclusionTo the best of our knowledge, this is the first report of clinicopathological features of pediatric and AYA patients in a large nationwide registry of renal biopsy. There were differences of clinical, pathological and histopathologic findings between pediatric and AYA patients.

Indexed as

AdolescentAdultAge DistributionBiopsyChildChild, PreschoolCross-Sectional StudiesFemaleGlomerular Filtration RateGlomerulonephritis, IGAGlomerulonephritis, MembranoproliferativeHumansInfantJapanKidney GlomerulusMaleAdolescentChronic kidney diseaseCross-sectional analysisNephrotic syndromeYoung adult

Identifiers

PMID34047871

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.