ArticleEuropean radiology2021
Opportunistic application of phantom-less calibration methods for fracture risk prediction using QCT/FEA.
Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A higher threshold of lumbar spine QCT trabecular BMD of < 95 or < 100 mg/mL for fragility fracture risk screening among Caucasian men than that of < 80 mg/mL for Caucasian women.Skeletal radiology · 2026Article
- Phantomless calibration of glenoid trabecular bone density: improved accuracy using age-stratified reference tissue densities.JBMR plus · 2026Article
- Beyond SINS: A Critical Review of Biomechanical, Microstructural, and Radiomic Biomarkers for Predicting Fracture Risk in Spinal Metastases.Diagnostics (Basel, Switzerland) · 2026Review
- Computational Assessment of Fracture Risk in Vertebral Bodies With Simulated Defects: The Role of Baseline Strength and Tumor Size.International journal for numerical methods in biomedical engineering · 2025Article
- Application of virtual monochromatic images in bone mineral density measurements: a phantom study.Scientific reports · 2025Article
- Establishing the effect of computed tomography reconstruction kernels on the measure of bone mineral density in opportunistic osteoporosis screening.Scientific reports · 2025Article
- Multi-site phantomless bone mineral density from clinical quantitative computed tomography in males.JBMR plus · 2024Article
- Developing and Validating a Model of Humeral Stem Primary Stability, Intended for In Silico Clinical Trials.Annals of biomedical engineering · 2024Article
- Phantomless calibration of CT scans for hip fracture risk prediction in silico: Comparison with phantom-based calibration.PloS one · 2024Article
- Performance of iCare quantitative computed tomography in bone mineral density assessment of the hip and vertebral bodies in European spine phantom.Journal of orthopaedic surgery and research · 2023Article
- Biomechanical Analysis of Palateless Splinted and Unsplinted Maxillary Implant-Supported Overdentures: A Three-Dimensional Finite Element Analysis.Materials (Basel, Switzerland) · 2023Article
- Opportunistic Screening Techniques for Analysis of CT Scans.Current osteoporosis reports · 2023Review
- A Review of CT-Based Fracture Risk Assessment with Finite Element Modeling and Machine Learning.Current osteoporosis reports · 2022Review
- Finite Element Assessment of Bone Fragility from Clinical Images.Current osteoporosis reports · 2021Review
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4 authors.
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Abstract
objectivesQuantitative computed tomography (QCT)-based finite element analysis (FEA) implements a calibration phantom to estimate bone mineral density (BMD) and assign material properties to the models. The objectives of this study were to (1) propose robust phantom-less calibration methods, using subject-specific tissues, to obtain vertebral fracture properties estimations using QCT/FEA; and (2) correlate QCT/FEA predictions to DXA values of areal BMD.
methodsEighty of a cohort of 111 clinical QCT scans were used to obtain subject-specific parameters using a phantom calibration approach and for the development of the phantom-less calibration equations. Equations were developed based on the HU measured from various soft tissues and regions, and using multiple linear regression analyses. Thirty-one additional QCT scans were used for cross-validation of QCT/FEA estimated fracture loads from the L
resultsOverall, 217 QCT/FEA models from 31 subjects (20 females, 11 men) with mean ages of 69.6 (13.1) and 67.3 (14) were used to cross-validate the phantom-less equations and assess bone strength. The proposed phantom-less equations showed high correlations with phantom-based estimates of BMD (99%). Cross-validation of QCT/FEA-predicted fracture loads from phantom-less equations and phantom-specific outcomes resulted in high correlations for all proposed methods (0.94-0.99). QCT/FEA correlation outcomes from the phantom-less equations and DXA-aBMD were moderately high (0.64-0.68).
conclusionsThe proposed QCT/FEA subject-specific phantom-less calibration methods demonstrated the potential to be applied to both prospective and retrospective applications in the clinical setting. KEY POINTS: • QCT/FEA overcomes the disadvantages of DXA and improves fracture properties predictions of vertebrae. • QCT/FEA fracture estimates using the phantom-less approach highly correlated to values obtained using a calibration phantom. • QCT/FEA prediction using a phantom-less approach is an accurate alternative over phantom-based methods.
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