Evidence map›Paper›PMID 34047652›Full record

ArticlemSphere2021

Collateral Sensitivity to β-Lactam Drugs in Drug-Resistant Tuberculosis Is Driven by the Transcriptional Wiring of BlaI Operon Genes.

A S Trigos, B W Goudey, J Bedő, T C Conway, N G Faux, K L Wyres

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Microbiology spectrum · 2023
    Article
  4. Transcriptional regulation and drug resistance inFrontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

A S TrigosPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
B W GoudeyThe School of Computing and Information Systems, The University of Melbourne, Parkville, Victoria, Australia.
J BedőThe School of Computing and Information Systems, The University of Melbourne, Parkville, Victoria, Australia.
T C ConwayPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
N G FauxMelbourne Data Analytics Platform, The University of Melbourne, North Melbourne, Victoria, Australia.
K L WyresDepartment of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
The University of Melbourne · AUMonash University · AUPeter MacCallum Cancer Centre · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The evolution of resistance to one antimicrobial can result in enhanced sensitivity to another, known as "collateral sensitivity." This underexplored phenomenon opens new therapeutic possibilities for patients infected with pathogens unresponsive to classical treatments. Intrinsic resistance to β-lactams in Mycobacterium tuberculosis (the causative agent of tuberculosis) has traditionally curtailed the use of these low-cost and easy-to-administer drugs for tuberculosis treatment. Recently, β-lactam sensitivity has been reported in strains resistant to classical tuberculosis therapy, resurging the interest in β-lactams for tuberculosis. However, a lack of understanding of the molecular underpinnings of this sensitivity has delayed exploration in the clinic. We performed gene expression and network analyses and

Indexed as

Anti-Bacterial Agentsbeta-Lactam Resistancebeta-LactamsComputer SimulationGene ExpressionGene Expression ProfilingHumansMicrobial Sensitivity TestsMycobacterium tuberculosisOperonTranscription, GeneticTuberculosis, Multidrug-ResistantAnti-Bacterial Agentsbeta-Lactamsantimicrobial resistancebioinformaticscollateral sensitivityin siliconetwork analysisparadoxical hypersensitivitytuberculosisβ-lactams

Identifiers

PMID34047652
PMCPMC8265638
OpenAlexW3164431957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.