Evidence map›Paper›PMID 34047504›Full record

SynthesisKorean journal of radiology2021

Accuracy of Digital Breast Tomosynthesis for Detecting Breast Cancer in the Diagnostic Setting: A Systematic Review and Meta-Analysis.

Min Jung Ko, Dong A Park, Sung Hyun Kim, Eun Sook Ko, Kyung Hwan Shin, Woosung Lim, Beom Seok Kwak, Jung Min Chang

Open access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Korean journal of radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  6. Local Diagnostic Reference Levels in Digital Breast Tomosynthesis.Journal of medical radiation sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Min Jung Ko *Division for Healthcare Technology Assessment Research, National Evidence-Based Healthcare Collaborating Agency, Seoul, Korea.ORCID 0000-0003-3599-7173
Dong A Park *Division for Healthcare Technology Assessment Research, National Evidence-Based Healthcare Collaborating Agency, Seoul, Korea.ORCID 0000-0001-7225-3152
Sung Hyun KimDivision for Healthcare Technology Assessment Research, National Evidence-Based Healthcare Collaborating Agency, Seoul, Korea.ORCID 0000-0001-9587-674X
Eun Sook KoDepartment of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID 0000-0002-0399-7956
Kyung Hwan ShinDepartment of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.ORCID 0000-0002-5852-7644
Woosung LimDepartment of Surgery, College of Medicine, Ewha Womans University, Seoul, Korea.ORCID 0000-0002-2863-9346
Beom Seok KwakDepartment of Surgery, Dongguk University Ilsan Hospital, Goyang, Korea.ORCID 0000-0003-0180-5102
Jung Min ChangDepartment of Radiology, Seoul National University Hospital, Seoul, Korea.ORCID 0000-0001-5726-9797
National Evidenc- based healthcare Collaborating Agency · KRSeoul National University · KRDongguk University Ilsan Hospital · KREwha Womans University · KRSamsung Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the accuracy for detecting breast cancer in the diagnostic setting between the use of digital breast tomosynthesis (DBT), defined as DBT alone or combined DBT and digital mammography (DM), and the use of DM alone through a systematic review and meta-analysis. MATERIALS AND

methodsOvid-MEDLINE, Ovid-Embase, Cochrane Library and five Korean local databases were searched for articles published until March 25, 2020. We selected studies that reported diagnostic accuracy in women who were recalled after screening or symptomatic. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. A bivariate random effects model was used to estimate pooled sensitivity and specificity. We compared the diagnostic accuracy between DBT and DM alone using meta-regression and subgroup analyses by modality of intervention, country, existence of calcifications, breast density, Breast Imaging Reporting and Data System category threshold, study design, protocol for participant sampling, sample size, reason for diagnostic examination, and number of readers who interpreted the studies.

resultsTwenty studies (n = 44513) that compared DBT and DM alone were included. The pooled sensitivity and specificity were 0.90 (95% confidence interval [CI] 0.86-0.93) and 0.90 (95% CI 0.84-0.94), respectively, for DBT, which were higher than 0.76 (95% CI 0.68-0.83) and 0.83 (95% CI 0.73-0.89), respectively, for DM alone (

conclusionUse of DBT was more accurate than DM alone for the diagnosis of breast cancer. Women with clinical symptoms or abnormal screening findings could be more effectively evaluated for breast cancer using DBT, which has a superior diagnostic performance compared to DM alone.

Indexed as

Breast NeoplasmsBreast DensityEarly Detection of CancerFemaleHumansMammographyMass ScreeningSensitivity and SpecificityBreast cancerBreast tomosynthesisMammographyMeta-analysisPerformance

Identifiers

PMID34047504
PMCPMC8316775
OpenAlexW3164411362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.