Adhesion-growth factor crosstalk regulates AURKB activation and ERK signalling in re-adherent fibroblasts.

Siddhi Inchanalkar, Nagaraj Balasubramanian

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In one paragraph

Article in Journal of biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Siddhi InchanalkarIndian Institute of Science Education and Research, Pashan, Pune 411 008, India.

Nagaraj Balasubramanian

Indian Institute of Science Education and Research Pune · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aurora kinases despite their similarity have distinct roles in the cell cycle, which is regulated by cell-matrix adhesion and growth factors. This study reveals loss of adhesion and re-adhesion to differentially regulate Aurora kinases. AURKB activation that drops on the loss of adhesion recovers on re-adhesion in serumdeprived conditions but not in the presence of serum growth factors. A rapid 30 min serum treatment of serumdeprived cells blocks the adhesion-dependent recovery of AURKB, which negatively correlates with Erk activation. AZD mediated inhibition of AURKB in serum-deprived re-adherent cells promotes Erk activation and membrane ruffling, comparable to presence of serum. These studies thus define a novel adhesion-growth factor-dependent regulation of AURKB that controls adhesion-dependent Erk activation in re-adherent fibroblasts.

Indexed as

AnimalsAurora Kinase AAurora Kinase BCell AdhesionCell CycleCell LineCulture Media, Serum-FreeEmbryo, MammalianFibroblastsGene Expression RegulationIntercellular Signaling Peptides and ProteinsMAP Kinase Signaling SystemMiceMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Aurka protein, mouseAurkb protein, mouseAurora Kinase AAurora Kinase BCulture Media, Serum-FreeIntercellular Signaling Peptides and ProteinsMapk1 protein, mouseMapk3 protein, mouseMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3

Identifiers

PMID34047289

OpenAlexW3165415616

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.