ReviewPaediatric drugs2021
Pain Management in Children: NSAID Use in the Perioperative and Emergency Department Settings.
Review in Paediatric drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Ibuprofen for acute postoperative pain in children.The Cochrane database of systematic reviews · 2024Pooled it
- Comparison of oral versus rectal NSAIDs for perioperative analgesia in pediatric circumcision using a disposable circumcision suture device: a randomized controlled trial.BMC anesthesiology · 2026Trial
- Pattern of use and awareness of side-effects of non-steroidal anti-inflammatory drugs among general public in Gondar city, North west Ethiopia.Scientific reports · 2026Article
- Effect of Local Anesthesia at the Bone Collection Site of Iliac Bone Grafting on Autonomic Nervous System Activity and Circulatory Dynamics in Alveolar Cleft Treatment.Pain research & management · 2026Article
- Perioperative pain in children: an opioid-sparing perspective.World journal of pediatrics : WJP · 2025Article
- Review
- Postoperative Analgesic Effects of Quadratus Lumborum Block Versus Transversus Abdominis Plane Block in Pediatric Lower Abdominal Surgeries: A Systematic Review and Meta-Analysis.Journal of pain research · 2025Review
- Updating Clinical Practice: Improving Perioperative Pain Management for Adeno-Tonsillectomy in Children.Children (Basel, Switzerland) · 2024Review
- Damage-associated molecular patterns as a mechanism of sevoflurane-induced neuroinflammation in neonatal rodents.Korean journal of anesthesiology · 2024Article
- Preoperative preparation and postoperative care in children in thoracic surgery.Turk gogus kalp damar cerrahisi dergisi · 2024Review
- Pain Management in Children Admitted to the Emergency Room: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Pain Evaluation and Treatment in Children: A Practical Approach.Children (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are often used for pediatric pain management in the emergency setting and postoperatively. This narrative literature review evaluates pain relief, opioid requirements, and adverse effects associated with NSAID use. A PubMed search was conducted to identify randomized controlled trials evaluating the use of conventional systemic NSAIDs as pain management for children in the perioperative or emergency department (traumatic injury) setting. Trials of cyclooxygenase-2 inhibitors ("coxibs") were excluded. Search results included studies of ibuprofen (n = 12), ketoprofen (n = 5), ketorolac (n = 6), and diclofenac (n = 4). NSAIDs reduced the opioid requirement in 10 of 13 studies in which this outcome was measured. NSAID use did not compromise pain relief; NSAIDs provided improved or similar pain scores compared with opioids (or other control) in 24 of 27 studies. Adverse event frequencies were reported in 26 studies; adverse event frequencies with NSAIDs were lower than with opioids (or other control) in three of 26 studies, similar in 21 of 26 studies, and more frequent in two of 26 studies. Perioperative and emergency department use of NSAIDs may reduce opioid requirements while maintaining pain control, with similar or reduced frequencies of opioid-associated adverse events.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.