SynthesisEnvironmental science and pollution research international2021
Lead exposure and its association with neurological damage: systematic review and meta-analysis.
Synthesis in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 28 citations in OpenAlex.
- Duckweed (Frontiers in nutrition · 2026Review
- A Review of the Evidence of the Toxicity of Chemical Substances Included in the European Union Ambient Air Quality and Drinking Water Directives: Perspectives for Health Impact Assessments.Environment & health (Washington, D.C.) · 2025Review
- Comparison between inductively coupled plasma-mass spectrometry and benchtop X-ray fluorescence performance for trace elemental exposure in rat tissues.Journal of trace elements and minerals · 2025Article
- The global burden of lead exposure-related ischemic stroke: based on Bayesian age-period-cohort analysis.Frontiers in public health · 2025Article
- Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies.F1000Research · 2025Review
- Article
- Neurotoxicity of Chronic Co-Exposure of Lead and Ionic Liquid in Common Carp: Synergistic or Antagonistic?International journal of molecular sciences · 2022Article
- Global Trends in Mortality and Burden of Stroke Attributable to Lead Exposure From 1990 to 2019.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lead (Pb) is one of the most toxic and abundant elements in the earth's crust, which is pointed out that the intoxication caused by it may damage biological systems. This systematic review with meta-analysis aimed to evaluate the association between Pb exposure and neurological damage. This work was executed according to PRISMA guidelines, and seven online databases were consulted. Based on the PECO strategy, studies presenting humans as participants (populations) exposed to Pb (exposure) compared to non-exposed to Pb (control) evaluating the neurological impairment (outcome) were included. The quality and risk of bias were verified by Fowkes and Fulton checklist. Two meta-analyses were conducted considering Digit Symbol and Profile Mood tests. The certainty of the evidence was evaluated with the GRADE tool. This review identified 2019 studies, of which 12 were eligible according to the inclusion criteria. Eight were considered with a low risk of bias. All the studies elected showed that exposure to Pb is associated with neurological damage, but the meta-analysis did not show any difference for the evaluated tests, and the certainty of the evidence was considered very low. Nevertheless, the included studies showed that Pb occupational exposure is associated with neurological damage, and the main parameters evaluated for possible neurological damage were related to mnemonic aspects, reaction time, intelligence, attention disorders, and mood changes. Thus, our results revealed that a definitive demonstration of an association of Pb and neurological changes in humans is still a pending issue. Future studies should take into consideration more confident methods to answer this question.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.