Evidence map›Paper›PMID 34046730›Full record

ArticleEJNMMI research2021

A dual-time-window protocol to reduce acquisition time of dynamic tau PET imaging using [

Guilherme D Kolinger, David Vállez García, Talakad G Lohith, Eric D Hostetler, Cyrille Sur, Arie Struyk, Ronald Boellaard, Michel Koole

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Changes in synaptic density in the subacute phase after ischemic stroke: AJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Trial
  2. Visual versus quantitative tau-PET Braak staging in Alzheimer's disease using [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Quantitative Measurement of Tau Burden in a Dual-Time-Window Dynamic PET Imaging Protocol with [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  4. Reproducibility of [EJNMMI physics · 2024
    Article
  5. Measurement of Cerebral Perfusion Indices from the Early Phase of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  6. Article
  7. Imaging pathological tau in atypical parkinsonisms: A review.Clinical parkinsonism & related disorders · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Guilherme D KolingerMedical Imaging Center, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
David Vállez GarcíaMedical Imaging Center, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Talakad G LohithTranslational Imaging Biomarkers, Merck & Co., Inc., 770 Sumneytown Pike, Mailstop WP44D-216, West Point, PA, 19486, USA.
Eric D HostetlerTranslational Imaging Biomarkers, Merck & Co., Inc., 770 Sumneytown Pike, Mailstop WP44D-216, West Point, PA, 19486, USA.
Cyrille SurTranslational Imaging Biomarkers, Merck & Co., Inc., 770 Sumneytown Pike, Mailstop WP44D-216, West Point, PA, 19486, USA.
Arie StruykTranslational Pharmacology, Merck & Co., Inc, 351 N Sumneytown Pike, Mailstop UG4D-48, North Wales, PA, 19454, USA.
Ronald Boellaard *Medical Imaging Center, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Michel Koole *Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Herestraat 49 - Bus 7003, 3000, Leuven, Belgium. michel.koole@kuleuven.be.ORCID http://orcid.org/0000-0001-5862-640X
United States Military Academy · USUniversity Medical Center Groningen · NLKU Leuven · BEMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

H2020 Marie Skłodowska-Curie Actions 764458
6 · The paper itself

Abstract

background[

resultsIt was found that DVR from a DTW protocol with a 60-min break between two 30-min dynamic scans closely approximates the DVR from the uninterrupted TAC

conclusionsTherefore, such DTW protocol has the potential to increase patient comfort and throughput without compromising quantitative accuracy and is more reliable against SUVR in terms of perfusion changes and protocol deviations, which could prove beneficial for drug effect assessment and patient follow-up using longitudinal [

Indexed as

[18F]MK-6240Dual-time-windowPET quantificationReference loganTau imaging

Identifiers

PMID34046730
PMCPMC8160074
OpenAlexW3163958509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.