Evidence map›Paper›PMID 34046622›Full record

ArticleRSC medicinal chemistry2021

Structural modifications that increase gut restriction of bile acid derivatives.

Ali Nakhi, Henry L Wong, Melissa Weldy, Alexander Khoruts, Michael J Sadowsky, Peter I Dosa

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. KThe Journal of pharmacology and experimental therapeutics · 2023
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Ali NakhiInstitute for Therapeutics Discovery and Development, Department of Medicinal Chemistry, University of Minnesota 717 Delaware Street SE Minneapolis Minnesota 55414 USA pidosa@umn.edu +1 612 626 6318 +1 612 625 7948.ORCID https://orcid.org/0000-0002-4366-9770
Henry L WongInstitute for Therapeutics Discovery and Development, Department of Medicinal Chemistry, University of Minnesota 717 Delaware Street SE Minneapolis Minnesota 55414 USA pidosa@umn.edu +1 612 626 6318 +1 612 625 7948.
Melissa WeldyBioTechnology Institute, University of Minnesota 1479 Gortner Avenue St. Paul Minnesota 55108 USA.
Alexander KhorutsBioTechnology Institute, University of Minnesota 1479 Gortner Avenue St. Paul Minnesota 55108 USA.
Michael J SadowskyBioTechnology Institute, University of Minnesota 1479 Gortner Avenue St. Paul Minnesota 55108 USA.
Peter I DosaInstitute for Therapeutics Discovery and Development, Department of Medicinal Chemistry, University of Minnesota 717 Delaware Street SE Minneapolis Minnesota 55414 USA pidosa@umn.edu +1 612 626 6318 +1 612 625 7948.ORCID https://orcid.org/0000-0002-0081-3867
University of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bile acid derivatives have been investigated as possible therapeutics for a wide array of conditions, including several for which gut-restricted analogs would likely be preferred. These include the prevention of

Identifiers

PMID34046622
PMCPMC8130628
OpenAlexW3132114803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.