Evidence map›Paper›PMID 34046613›Full record

ArticleRSC medicinal chemistry2021

Normal breast epithelial MCF-10A cells to evaluate the safety of carbon dots.

Nuno Vale, Sara Silva, Diana Duarte, Diana M A Crista, Luís Pinto da Silva, Joaquim C G Esteves da Silva

Open access · greenAbstract read
In one paragraph

Article in RSC medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Pinostrobin pentanoate as a selective estrogen receptor-Research in pharmaceutical sciences · 2026
    Article
  3. Cetyl All-International journal of molecular sciences · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. QSAR Modeling for Predicting ICInternational journal of molecular sciences · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. (Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  13. Design, synthesis, biological andBiomedical reports · 2025
    Article
  14. Molecules (Basel, Switzerland) · 2024
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. LC-HR/MS Analysis of Lipophilic Extracts fromMolecules (Basel, Switzerland) · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 3 countries.

Nuno ValeOncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS) Rua Dr. Plácido da Costa 4200-450 Porto Portugal.ORCID https://orcid.org/0000-0002-1283-1042
Sara SilvaOncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS) Rua Dr. Plácido da Costa 4200-450 Porto Portugal.ORCID https://orcid.org/0000-0001-8164-2504
Diana DuarteOncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS) Rua Dr. Plácido da Costa 4200-450 Porto Portugal.ORCID https://orcid.org/0000-0003-1420-5042
Diana M A CristaChemistry Research Unit (CIQUP), Faculty of Sciences of University of Porto (FCUP) Rua do Campo Alegre 687 4169-007 Porto Portugal luis.silva@fc.up.pt,jcsilva@fc.up.pt.ORCID https://orcid.org/0000-0001-9892-8613
Luís Pinto da SilvaChemistry Research Unit (CIQUP), Faculty of Sciences of University of Porto (FCUP) Rua do Campo Alegre 687 4169-007 Porto Portugal luis.silva@fc.up.pt,jcsilva@fc.up.pt.ORCID https://orcid.org/0000-0002-5647-8455
Joaquim C G Esteves da SilvaChemistry Research Unit (CIQUP), Faculty of Sciences of University of Porto (FCUP) Rua do Campo Alegre 687 4169-007 Porto Portugal luis.silva@fc.up.pt,jcsilva@fc.up.pt.ORCID https://orcid.org/0000-0001-8478-3441
Universidade do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human normal breast cell line MCF-10A is being widely used as a model in toxicity studies due to its structural similarity to the normal human mammary epithelium. Over the years, application of carbon dots (C-dots) in biomedicine has been increasing due to their photoluminescence properties, biocompatibility, biosafety and possible applications in bioimaging and as drug carriers. In this work we prepared three different C-dots from the same set of carbon and nitrogen precursors (citric acid and urea, respectively)

Identifiers

PMID34046613
PMCPMC8128052
OpenAlexW3112212898

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.