Evidence map›Paper›PMID 34046604›Full record

ArticleRSC medicinal chemistry2021

Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents.

Julia Fernández de Luco, Alejandro I Recio-Balsells, Diego G Ghiano, Ana Bortolotti, Juán Manuel Belardinelli, Nina Liu, Pascal Hoffmann, Christian Lherbet, Peter J Tonge, Babu Tekwani and 2 more

Open access · greenAbstract read
In one paragraph

Article in RSC medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Triclosan: A Small Molecule with Controversial Roles.Antibiotics (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 6 countries.

Julia Fernández de LucoInstituto de Química Rosario, UNR, CONICET Suipacha 531 S2002LRK Rosario Argentina labadie@iquir-conicet.gov.ar +54 341 4370477 +54 341 4370477.ORCID https://orcid.org/0000-0003-2438-7978
Alejandro I Recio-BalsellsInstituto de Química Rosario, UNR, CONICET Suipacha 531 S2002LRK Rosario Argentina labadie@iquir-conicet.gov.ar +54 341 4370477 +54 341 4370477.ORCID https://orcid.org/0000-0002-9688-4589
Diego G GhianoInstituto de Química Rosario, UNR, CONICET Suipacha 531 S2002LRK Rosario Argentina labadie@iquir-conicet.gov.ar +54 341 4370477 +54 341 4370477.
Ana BortolottiLaboratorio de Microbiología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Rosario Santa Fe 3100 S2002KTR Rosario Argentina morbiatny@yahoo.com.
Juán Manuel BelardinelliLaboratorio de Microbiología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Rosario Santa Fe 3100 S2002KTR Rosario Argentina morbiatny@yahoo.com.
Nina LiuDepartment of Chemistry, Institute of Chemical Biology & Drug Discovery, Stony Brook University Stony Brook NY 11794 USA.
Pascal HoffmannLSPCMIB, UMR-CNRS 5068, Université Paul Sabatier-Toulouse III 118 Route de Narbonne 31062 Toulouse Cedex 9 France.
Christian LherbetLSPCMIB, UMR-CNRS 5068, Université Paul Sabatier-Toulouse III 118 Route de Narbonne 31062 Toulouse Cedex 9 France.
Peter J TongeDepartment of Chemistry, Institute of Chemical Biology & Drug Discovery, Stony Brook University Stony Brook NY 11794 USA.ORCID https://orcid.org/0000-0003-1606-3471
Babu TekwaniNational Center for Natural Products Research & Department of Biomolecular Sciences, School of Pharmacy, University of Mississippi MS 38677 USA.
Héctor R MorbidoniLaboratorio de Microbiología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Rosario Santa Fe 3100 S2002KTR Rosario Argentina morbiatny@yahoo.com.ORCID https://orcid.org/0000-0003-4180-9677
Guillermo R LabadieInstituto de Química Rosario, UNR, CONICET Suipacha 531 S2002LRK Rosario Argentina labadie@iquir-conicet.gov.ar +54 341 4370477 +54 341 4370477.ORCID https://orcid.org/0000-0003-2467-1573
Centro Científico Tecnólogico - Rosario · ARUniversidad de Ciencias Medicas · CRCentre National de la Recherche Scientifique · FRStony Brook Medicine · USUniversity of Mississippi · US

Funding

Mechanism of Slow Onset Enzyme Inhibition and Translation to Time-Dependent Drug ActivityR01GM102864 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI TONGE, PETER J · 2012 to 2021
$2.6M
Medical Research Council MR/P027989/1NIGMS NIH HHS R01 GM102864
6 · The paper itself

Abstract

Triclosan and isoniazid are known antitubercular compounds that have proven to be also active against

Identifiers

PMID34046604
PMCPMC8130612
OpenAlexW3097625261

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.