Evidence map›Paper›PMID 34046600›Full record

ArticleRSC medicinal chemistry2021

Structure-activity relationship studies on 2,5,6-trisubstituted benzimidazoles targeting

Krupanandan Haranahalli, Simon Tong, Saerom Kim, Monaf Awwa, Lei Chen, Susan E Knudson, Richard A Slayden, Eric Singleton, Riccardo Russo, Nancy Connell and 1 more

Open access · greenAbstract read
In one paragraph

Article in RSC medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Krupanandan HaranahalliInstitute of Chemical Biology and Drug Discovery, Stony Brook University Stony Brook NY USA iwao.ojima@stonybrook.edu.
Simon TongDepartment of Chemistry, Stony Brook University Stony Brook NY USA.
Saerom KimDepartment of Chemistry, Stony Brook University Stony Brook NY USA.
Monaf AwwaDepartment of Chemistry, Stony Brook University Stony Brook NY USA.
Lei ChenDepartment of Chemistry, Stony Brook University Stony Brook NY USA.
Susan E KnudsonDepartment of Microbiology, Immunology and Pathology, Colorado State University Fort Collins Colorado 80523-1682 USA.
Richard A SlaydenDepartment of Microbiology, Immunology and Pathology, Colorado State University Fort Collins Colorado 80523-1682 USA.
Eric SingletonDepartment of Medicine, Center for Emerging and Re-emerging Pathogens, Rutgers University Newark New Jersey 07103 USA.
Riccardo RussoDepartment of Medicine, Center for Emerging and Re-emerging Pathogens, Rutgers University Newark New Jersey 07103 USA.
Nancy ConnellDepartment of Medicine, Center for Emerging and Re-emerging Pathogens, Rutgers University Newark New Jersey 07103 USA.
Iwao OjimaInstitute of Chemical Biology and Drug Discovery, Stony Brook University Stony Brook NY USA iwao.ojima@stonybrook.edu.ORCID https://orcid.org/0000-0002-3628-1161
Stony Brook Medicine · USRutgers, The State University of New Jersey · USColorado State University · US

Funding

Development and Formulation of Broad Spectrum Antimicrobials for BiodefenseU01AI082164 · NIAID · COLORADO STATE UNIVERSITY · PI SLAYDEN, RICHARD A · 2009 to 2010
$2.0M
Novel Antimicrobials Targeting Cell DivisionR01AI078251 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI OJIMA, IWAO · 2009 to 2013
$1.9M
NIAID NIH HHS R01 AI078251NIAID NIH HHS U01 AI082164
6 · The paper itself

Abstract

Filamenting temperature sensitive protein Z (FtsZ) is an essential bacterial cell division protein and a promising target for the development of new antibacterial therapeutics. As a part of our ongoing SAR studies on 2,5,6-trisubstituted benzimidazoles as antitubercular agents targeting

Identifiers

PMID34046600
PMCPMC8132993
OpenAlexW3093385608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.