Evidence map›Paper›PMID 34046553›Full record

ArticleCephalalgia reports2019

Low-frequency facial hemodynamic oscillations distinguish migraineurs from non-headache controls.

Melissa M Cortez, Jeremy J Theriot, Natalie A Rea, Forrest E Gowen, K C Brennan

Open access · goldAbstract read
In one paragraph

Article in Cephalalgia reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Melissa M CortezDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Jeremy J TheriotDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Natalie A ReaSchool of Medicine, University of Utah, Salt Lake City, UT, USA.
Forrest E GowenSchool of Medicine, University of Nevada, Reno, NV, USA.
K C BrennanDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0003-4193-5841
University of Utah · USUniversity of Nevada, Reno · US

Funding

Astrocytic mechanisms in a new genetic model of migraineR01NS104742 · NINDS · UNIVERSITY OF UTAH · PI BRENNAN, KEVIN CHRISTOPHER · 2018 to 2022
$2.5M
Sensory plasticity in migraineR01NS085413 · NINDS · UNIVERSITY OF UTAH · PI BRENNAN, KEVIN CHRISTOPHER · 2013 to 2017
$1.7M
Cortical Spreading Depression in the Origins of the Migraine AttackR01NS102978 · NINDS · UNIVERSITY OF UTAH · PI BRENNAN, KEVIN CHRISTOPHER · 2017 to 2021
$1.7M
NIMHD NIH HHS L32 MD009927NINDS NIH HHS R01 NS085413NINDS NIH HHS R01 NS102978NINDS NIH HHS R01 NS104742
6 · The paper itself

Abstract

backgroundSurface imaging is a promising, noninvasive approach to assess regional perfusion in craniovascular disorders such as migraine.

methodsWe used optical imaging to examine differences in facial blood volume at baseline and in response to ammonia inhalation (a noxious stimulus), as well as standardized measures of cardiovascular autonomic function, in healthy, non-headache controls (

resultsResting facial cutaneous oscillation (FCO) frequency was significantly different in migraine compared to healthy controls. Following ammonia inhalation, healthy controls showed a significant increase in resting FCO frequency, whereas this response was not significant in the migraine group. Standardized autonomic reflex parameters did not differ significantly between study groups, and facial cutaneous activity did not correlate with standardized cardiovascular autonomic reflex parameters, suggesting potentially different regulation.

conclusionsThis approach to the assessment of craniofacial hemodynamic function appears to exhibit differing mechanisms from previously available techniques, and represents a promising new physiological biomarker for the study of craniofacial vascular function in migraine and potentially other craniovascular disorders.

Indexed as

autonomiccraniofacial perfusionmigrainesurface imagingtrigeminovascular

Identifiers

PMID34046553
PMCPMC8153087
OpenAlexW2984177921

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.