Evidence map›Paper›PMID 34046506›Full record

ArticleJournal of immunology research2021

Neuroprotective Effects of

Zhanglong Peng, Supinder Bedi, Vivek Mann, Alamelu Sundaresan, Kohei Homma, Gregory Gaskey, Minoru Kowada, Shahid Umar, Anil D Kulkarni, Holger K Eltzschig and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Frontiers in nutrition · 2026
    Pooled it
  2. Effect of a Standardized Extract ofEvidence-based complementary and alternative medicine : eCAM · 2023
    Article
  3. Standardized Extract ofMolecules (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Zhanglong PengDepartment of Anesthesiology, McGovern Medical Houston, TX, USA.
Supinder BediPediatric Surgery, McGovern Medical Houston, TX, USA.
Vivek MannDepartment of Biology, Texas Southern University, Houston, TX, USA.
Alamelu SundaresanDepartment of Biology, Texas Southern University, Houston, TX, USA.
Kohei HommaAmino Up, Sapporo, Japan.
Gregory GaskeyDepartment of Anesthesiology, McGovern Medical Houston, TX, USA.
Minoru KowadaGeneral Surgery, McGovern Medical Houston, TX, USA.
Shahid UmarDepartment of Surgery, University of Kansas, Kansas City, KS, USA.
Anil D KulkarniGeneral Surgery, McGovern Medical Houston, TX, USA.
Holger K EltzschigDepartment of Anesthesiology, McGovern Medical Houston, TX, USA.
Marie-Francoise DoursoutDepartment of Anesthesiology, McGovern Medical Houston, TX, USA.ORCID https://orcid.org/0000-0002-5684-3483
Texas Southern University · USAmino Up (Japan) · JPUniversity of Kansas · US

Funding

microRNA miR-147 Dampens Alveolar Epithelial Inflammation During ARDSR01HL154720 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2021 to 2024
$2.2M
Hypoxia-Inducible Factors in Acetaminophen-Induced Liver Injury.R01DK109574 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K., JU, CYNTHIA · 2016 to 2019
$1.8M
Targeting MicroRNA miR-122 for the Treatment of Perioperative Liver InjuryR01DK122796 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K., JU, CYNTHIA · 2020 to 2023
$1.8M
MicroRNA Shuttling during Acute Respiratory Distress SyndromeR01HL133900 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2017 to 2020
$1.5M
NHLBI NIH HHS R01 HL133900NIDDK NIH HHS R01 DK109574
6 · The paper itself

Abstract

To mimic Alzheimer's disease, transgenic mice overexpressing the amyloid precursor protein (APP) were used in this study. We hypothesize that the neuroprotective effects of ETAS®50, a standardized extract of

Indexed as

Alzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsAsparagus PlantCognitionDisease Models, AnimalFemaleHippocampusHSP27 Heat-Shock ProteinsHSP70 Heat-Shock ProteinsHumansMaleMemoryMiceMice, TransgenicMorris Water Maze TestAmyloid beta-Protein PrecursorHSP27 Heat-Shock ProteinsHSP70 Heat-Shock ProteinsHspb2 protein, mouseNeuroprotective AgentsPlant ExtractsPresenilin-1PSEN1 protein, human

Identifiers

PMID34046506
PMCPMC8128539
OpenAlexW3163742182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.