Evidence map›Paper›PMID 34046428›Full record

ArticleFrontiers in molecular biosciences2021

Synthesis and Cytotoxic Activity of Novel Indole Derivatives and Their

Perumal Gobinath, Ponnusamy Packialakshmi, Kaliappillai Vijayakumar, Magda H. Abdellattif, Mohd Shahbaaz, Akbar Idhayadhulla, Radhakrishnan Surendrakumar

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Perumal GobinathPG & Research, Department of Chemistry, Nehru Memorial College (Affiliated Bharathidasan University), Puthanampatti, India.
Ponnusamy PackialakshmiPG & Research, Department of Chemistry, Nehru Memorial College (Affiliated Bharathidasan University), Puthanampatti, India.
Kaliappillai VijayakumarDepartment of Chemistry, M. Kumarasamy College of Enginnering, Karur, India.
Magda H. AbdellattifDepartment of Chemistry, College of Science, Deanship of Scientific Research, Taif University, Taif, Saudi Arabia.
Mohd ShahbaazSouth African Medical Research Council Bioinformatics Unit, South African National Bioinformatics Institute, University of the Western Cape, Cape Town, South Africa.
Akbar IdhayadhullaPG & Research, Department of Chemistry, Nehru Memorial College (Affiliated Bharathidasan University), Puthanampatti, India.
Radhakrishnan SurendrakumarPG & Research, Department of Chemistry, Nehru Memorial College (Affiliated Bharathidasan University), Puthanampatti, India.
Bharathidasan University · INM. Kumarasamy College of EngineeringSouth Ural State University · RUTaif University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work investigated the interaction of indole with SARS-CoV-2. Indole is widely used as a medical material owing to its astounding biological activities. Indole and its derivatives belong to a significant category of heterocyclic compounds that have been used as a crucial component for several syntheses of medicine. A straightforward one-pot three-component synthesis of indole, coupled with Mannich base derivatives 1a-1j, was synthesized without a catalyst. The products were confirmed by IR,

Indexed as

COVID-19cytotoxic activityindoleMannich basespike protein

Identifiers

PMID34046428
PMCPMC8144490
OpenAlexW4206254670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.