Evidence map›Paper›PMID 34046380›Full record

ArticleFrontiers in public health2021

Causal Effects of Body Mass Index on Airflow Obstruction and Forced Mid-Expiratory Flow: A Mendelian Randomization Study Taking Interactions and Age-Specific Instruments Into Consideration Toward a Life Course Perspective.

Nicole Probst-Hensch, Ayoung Jeong, Daiana Stolz, Marco Pons, Paola M Soccal, Robert Bettschart, Deborah Jarvis, John W Holloway, Florian Kronenberg, Medea Imboden and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Prevalence of Overweight and Obesity and Their Impact on Lung Function in Healthy Bulgarian Children and Adolescents: A Cross-Sectional Study.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Observational
  9. Review
  10. Swiss Cohort & Biobank - The White Paper.Public health reviews · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 4 countries.

Nicole Probst-HenschDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Ayoung JeongDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Daiana StolzClinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital Basel, Basel, Switzerland.
Marco PonsDivision of Pulmonary Medicine, Regional Hospital of Lugano, Lugano, Switzerland.
Paola M SoccalDivision of Pulmonary Medicine, Geneva University Hospitals, Geneva, Switzerland.
Robert BettschartLungenpraxis Aarau, Hirslanden Klinik, Aarau, Switzerland.
Deborah JarvisMedical Research Council-Public Health England, Centre for Environment and Health, Imperial College London, London, United Kingdom.
John W HollowayHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Florian KronenbergDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Medea ImbodenDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Christian SchindlerDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Gianfranco F LovisonDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
University of Basel · CHHirslanden Klinik Aarau · CHMedical Research Council · GBOspedale regionale di Lugano · CHSwiss Tropical and Public Health Institute · CHUniversität Innsbruck · ATUniversity Hospital of Basel · CHUniversity Hospital of Geneva · CHUniversity of Southampton · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Obesity has complex links to respiratory health. Mendelian randomization (MR) enables assessment of causality of body mass index (BMI) effects on airflow obstruction and mid-expiratory flow. In the adult SAPALDIA cohort, recruiting 9,651 population-representative samples aged 18-60 years at baseline (female 51%), BMI and the ratio of forced expiratory volume in 1 second (FEV

Indexed as

Mendelian Randomization AnalysisPulmonary Disease, Chronic ObstructiveAdultAge FactorsBody Mass IndexCross-Sectional StudiesFemaleHumansLungbody mass indexCOPDgenetic scorelongitudinal cohortlung functionMendelian randomization

Identifiers

PMID34046380
PMCPMC8144328
OpenAlexW3161730511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.