Evidence map›Paper›PMID 34046345›Full record

ArticleFrontiers in oncology2021

Cardiovascular Death Risk in Primary Central Nervous System Lymphoma Patients Treated With Chemotherapy: A Registry-Based Cohort Study.

Tianwang Guan, Zicong Qiu, Miao Su, Jinming Yang, Yongshi Tang, Yanting Jiang, Dunchen Yao, Yanxian Lai, Yanfang Li, Cheng Liu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Tianwang GuanDepartment of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Zicong QiuDepartment of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Miao SuDepartment of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Jinming YangDepartment of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Yongshi TangDepartment of Clinical Medicine, Clinical Medical School, Guangzhou Medical University, Guangzhou, China.
Yanting JiangDepartment of Clinical Medicine, Clinical Medical School, Guangzhou Medical University, Guangzhou, China.
Dunchen YaoDepartment of Oncology, Guiqian International General Hospital, Guiyang, China.
Yanxian LaiDepartment of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Yanfang LiDepartment of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Cheng LiuDepartment of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Guangzhou Medical University · CNGuangzhou First People's Hospital · CNSouth China University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo study the cardiovascular death (CVD) risk in primary central nervous system lymphoma (PCNSL) patients with chemotherapy.

methodsWe obtained 2,020 PCNSL participants and 88,613 non-central nervous system lymphoma (NCNSL) participants with chemotherapy from Surveillance, Epidemiology, and End Results (SEER) database from 2004 to 2015. A 1:3 propensity score matching (PSM) was used to reduce the imbalance between PCNSL participants with and without chemotherapy, as well as the imbalance between PCNSL and NCNSL participants with chemotherapy. Competing risks regressions were conducted to evaluate the independent influence of chemotherapy on CVD.

resultsAfter 1:3 PSM, the CVD risk in PCNSL patients with chemotherapy was lower than those without chemotherapy [decreased 53%, adjusted HR, 0.469 (95% CI, 0.255-0.862;

conclusionPCNSL patients with chemotherapy are associated with lower CVD risk. Our findings may provide new foundations for that chemotherapy is the first-line treatment for PCNSL patients, according to a cardiovascular risk perspective.

Indexed as

cardio-oncologycardiovascular deathchemotherapynon-central nervous system lymphomaprimary central nervous system lymphomaSEER

Identifiers

PMID34046345
PMCPMC8147725
OpenAlexW3160883504

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.