Evidence map›Paper›PMID 34046266›Full record

ArticlePeerJ2021

Microsatellite instability and Epstein-Barr virus combined with PD-L1 could serve as a potential strategy for predicting the prognosis and efficacy of postoperative chemotherapy in gastric cancer.

Na Yang, Yanhua Wu, Meishan Jin, Zhifang Jia, Yueqi Wang, Donghui Cao, Lili Qin, Xueying Wang, Min Zheng, Xueyuan Cao and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

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  13. Intratumoral CD8Journal of gastrointestinal oncology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Na Yang *Division of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province, China.
Yanhua Wu *Division of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province, China.
Meishan JinDivision of Pathology, First Hospital of Jilin University, Changchun, Jilin Province, China.
Zhifang JiaDivision of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province, China.
Yueqi WangDivision of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province, China.
Donghui CaoDivision of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province, China.
Lili QinDivision of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province, China.
Xueying WangDivision of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province, China.
Min ZhengDivision of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province, China.
Xueyuan CaoDepartment of Gastric and Colorectal Surgery, First Hospital of Jilin University, Changchun, Jilin Province, China.
Jing JiangDivision of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province, China.
Jilin University · CNFirst Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMicrosatellite instability (MSI) and Epstein-Barr virus (EBV)-positive molecular subtypes exhibit complex immune responses in gastric cancer (GC), and PD-L1 has emerged as a prognostic biomarker associated with the cancer immune microenvironment. This study aimed to determine the prognostic value of molecular subtypes and whether the addition of PD-L1 would accurately predict the prognosis and guide postoperative chemotherapy for GC patients.

methodsWe performed molecular subtyping of tissue microarray slides from 226 GC patients who were treated with radical gastrectomy. The MSI status and PD-L1 expression were evaluated through immunohistochemistry (IHC) and EBV status through situ hybridization. Multiplex polymerase chain reaction (PCR) was also performed on 50 cases to validate the accuracy of IHC in defining MSI status. Differences in overall survival (OS) were assessed using the Kaplan-Meier method, log-rank test and Cox proportional hazards regression model.

resultsAmong the 226 GC patients, 52 (23.2%) patients were classified as the MSI subtype, 11 (4.9%) were EBV

conclusionsMolecular subtyping combined with PD-L1 expression could serve as a potential strategy to better predict prognosis and guide postoperative chemotherapy of GC patients.

Indexed as

Epstein-Barr virusGastric cancerMicrosatellite instabilityOverall survivalPD-L1Postoperative chemotherapy

Identifiers

PMID34046266
PMCPMC8139270
OpenAlexW3162326813

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.