Evidence map›Paper›PMID 34046196›Full record

Trial reportFuture science OA2021

Breast cancer in previously thyroidectomized patients: which thyroid disorders are a risk factor?

Giuseppa Graceffa, Gregorio Scerrino, Gabriella Militello, Iole Laise, Brenda Randisi, Giuseppina Melfa, Giuseppina Orlando, Sergio Mazzola, Calogero Cipolla, Gianfranco Cocorullo

Open access · goldAbstract readClinical TrialReview
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Future science OA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Thyroid Diseases and Breast Cancer.Journal of personalized medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Giuseppa GraceffaDepartment of Surgical Oncology & Oral Sciences, Unit of Oncological Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.
Gregorio ScerrinoDepartment of Surgical Oncology & Oral Sciences, Unit of General & Emergency Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.
Gabriella MilitelloDepartment of Surgical Oncology & Oral Sciences, Unit of General & Emergency Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.
Iole LaiseDepartment of Surgical Oncology & Oral Sciences, Unit of Oncological Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.
Brenda RandisiDepartment of Surgical Oncology & Oral Sciences, Unit of General & Emergency Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.
Giuseppina MelfaDepartment of Surgical Oncology & Oral Sciences, Unit of General & Emergency Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.
Giuseppina OrlandoDepartment of Surgical Oncology & Oral Sciences, Unit of General & Emergency Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.
Sergio MazzolaUnit of Clinical Epidemiology & Tumor Registry, Department of Laboratory Diagnostics, Policlinico P. Giaccone University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.
Calogero CipollaDepartment of Surgical Oncology & Oral Sciences, Unit of Oncological Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.
Gianfranco CocorulloDepartment of Surgical Oncology & Oral Sciences, Unit of Oncological Surgery, University of Palermo, Via L Giuffré, 5, Palermo, 90127, Italy.
University of Palermo · ITAzienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to evaluate whether there are thyroid diseases in which breast cancer will appear later as well as the role of autoimmunity. This was a retrospective observational study. A total of 410 females (thyroid surgery and later breast cancer) and 524 females (thyroid surgery only) were compared with regard to pathological thyroid findings, thyroid hormones, thyroid autoimmunity and type of breast cancer. Thyroid autoimmunity, especially antithyroid peroxidase antibodies, significantly increased the risk of breast cancer (p < 0.01); however, this was not true for other thyroid diseases, including thyroid cancer. No variant of breast cancer was predominant, and only thyroid autoimmunity was associated with the risk of breast cancer. Further research is needed to explain the impacts of different antithyroid antibodies.

Indexed as

breast cancerthyroid autoantibodiesthyroid autoimmunitythyroid carcinomathyroid disordersthyroid dysfunctions

Identifiers

PMID34046196
PMCPMC8147746
OpenAlexW3145459850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.