ArticleThe Pan African medical journal2021
Prevalence and factors associated with hypertension among people living with HIV/AIDS on antiretroviral therapy in Uganda.
Article in The Pan African medical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Burden and Challenges of Managing Hypertension in People Living with Human Immunodeficiency Virus (HIV) Infection in Sub-Saharan Africa: A Mixed Systematic Review and Meta-Analysis.International journal of public health · 2025Pooled it
- Hypertension among people living with human immunodeficiency virus in sub-Saharan Africa: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Prevalence and factors associated with hypertension among peoples living with HIV in East Africa, a systematic review and meta-analysis.BMC infectious diseases · 2023Pooled it
- Early findings from the integration of hypertension care into differentiated service delivery models for HIV in Uganda: a mixed-method study.Journal of the International AIDS Society · 2025Trial
- Incidence of hypertension and factors associated with blood pressure control among older adults living with HIV in Western Kenya: a retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Prevalence and risk factors of hypertension and diabetes among persons living with HIV in Zambia: results of a national facility-based cross-sectional survey.Journal of the International AIDS Society · 2025Article
- Prolonged antiretroviral therapy use and hypertension in a retrospective cross-sectional study-Rakai, Uganda.BMC infectious diseases · 2025Article
- Interaction Effect of Depression and Hypertension on Nephrotoxicity Among Persons Living With HIV: A Cross-Sectional Study.International journal of nephrology · 2025Article
- Cost analysis of adding hypertension and diabetes management into routine HIV care in Mbarara and Ibanda districts, Uganda.BMC health services research · 2024Article
- Persistent low-level viraemia is associated with non-infectious comorbidities in an observational cohort in four African countries.Journal of the International AIDS Society · 2024Observational
- Coprevalence and associations of diabetes mellitus and hypertension among people living with HIV/AIDS in Cameroon.AIDS research and therapy · 2024Article
- HIV-Associated Hypertension: Risks, Mechanisms, and Knowledge Gaps.Circulation research · 2024Review
- Prevalence of Hypertension and Its Associated Factors Among Adults Living with HIV on Antiretroviral Treatment in Selected Public Hospitals in Addis Ababa, Ethiopia.HIV/AIDS (Auckland, N.Z.) · 2024Article
- Prevalence, Awareness, and Factors Associated with Hypertension Among People Living with HIV in Eastern Uganda. A Multicentre Cross-Sectional Study.HIV/AIDS (Auckland, N.Z.) · 2024Article
- Associations of anaemia with blood pressure in women of reproductive age: a cross-sectional study in Johannesburg, South Africa.The Pan African medical journal · 2024Article
- Blood pressure changes during tenofovir-based antiretroviral therapy among people living with HIV in Lilongwe, Malawi: results from the prospective LighTen Cohort Study.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- The burden of non-communicable diseases among people living with HIV in Sub-Saharan Africa: a systematic review and meta-analysis.EClinicalMedicine · 2023Article
- Review
- Integrated multi-month dispensing of antihypertensive and antiretroviral therapy to sustain hypertension and HIV control.Journal of human hypertension · 2023Article
- Lipids and apolipoproteins C-III and E among treatment-naïve and treatment-experienced persons with HIV in Nigeria.African journal of laboratory medicine · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionantiretroviral therapy (ART) has improved survival of People Living with HIV (PLWH); however, this has resulted in an increasingly high prevalence of non-communicable diseases (NCD) like hypertension. Hypertension is a major risk factor for cardiovascular and cerebral vascular disease, which are both associated with high morbidity and mortality rates. We studied the prevalence and factors associated with hypertension among PLWH on ART.
methodswe conducted a retrospective data analysis of PLWH on ART enrolled between 2011 and 2014 into a randomized double-blinded placebo-controlled trial investigating the safety of discontinuing cotrimoxazole prophylaxis (COSTOP) among PLWH in Central Uganda. We used the mean blood pressure (BP) measurements of the first four monthly clinic visits to define hypertension. Patients were categorised as: having normal BP (≤120/80mmHg), elevated BP (systolic >120-129, and diastolic ≤80), Stage 1 hypertension (systolic 130-139, or diastolic >80-89) and Stage 2 hypertension (systolic ≥140 or diastolic ≥90). Multiple logistic regression was used to evaluate factors associated with hypertension.
resultsdata from 2026 COSTOP trial study participants were analysed, 74.1% were women and 77.2% were aged 35 years and above. The overall prevalence of hypertension was 29%, of whom 19.5% had Stage 1 hypertension and 9.5% had Stage 2 hypertension. About 21.4% were overweight or obese. Factors independently associated with hypertension among PLWH on ART included increasing age (p≤0.001) and high body mass index (p≤0.001). Efavirenz (p≤0.001) and lopinavir/ritonavir (p=0.036) based regimen had lower odds of hypertension than Nevirapine based regimens.
conclusionPLWH on ART have a high prevalence of hypertension, which rises with increasing age and body mass index (BMI) and among those on nevirapine-based ART. Implementation of hypertension prevention measures among PLWH on ART and integration of NCD and HIV care to improve patients' management outcomes are required.
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