ReviewTherapeutic advances in gastroenterology2021
Review of pregnancy in Crohn's disease and ulcerative colitis.
Review in Therapeutic advances in gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Bridging the Pregnancy Knowledge Gap: A Real-World Analysis of Medication Use and Drug-Drug Interaction Risk in Crohn's Disease and Multiple Sclerosis.Clinical and translational science · 2026Article
- Relationship between pregnancy, delivery, and ileal pouch-anal anastomosis for inflammatory bowel disease: a retrospective chart review.Crohn's & colitis 360 · 2026Article
- Burden and Trends of Crohn's Disease Among Women of Reproductive Age in China, India, and the United States, 1990-2023, with Projections to 2040: A Systematic Analysis for the Global Burden of Disease Study 2023.International journal of women's health · 2026Article
- Neonatal and Pregnancy Outcomes in Pregnant Adults With Pediatric-Onset Crohn's Disease.Gastro hep advances · 2026Article
- Article
- Offspring exposure to Crohn's disease during pregnancy and association with milder psychiatric regulatory disturbances in childhood.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Expression Profile of MicroRNAs in Breast Milk of Women With Inflammatory Bowel Disease: Correlation With Disease Activity and Medical Treatments.Inflammatory bowel diseases · 2025Article
- Reproductive and sexual health concerns in gastrointestinal illness: a narrative review.Translational gastroenterology and hepatology · 2025Review
- Article
- Trends in medications for autoimmune disorders during pregnancy and factors for their discontinuation: a population-based study.BMC pregnancy and childbirth · 2024Article
- Effects of famotidine use during pregnancy: an observational cohort study.Journal of pharmaceutical health care and sciences · 2024Article
- A Gender Perspective on Coloproctological Diseases: A Narrative Review on Female Disorders.Journal of clinical medicine · 2024Review
- Patterns of reproductive health in inflammatory rheumatic diseases and other immune-mediated diseases: a nationwide registry study.Rheumatology (Oxford, England) · 2024Article
- Pregnancy Outcomes in Patients Treated with Upadacitinib: Analysis of Data from Clinical Trials and Postmarketing Reports.Drug safety · 2024Article
- Appropriateness of small molecule agents for patients with IBD of childbearing age - a RAND/UCLA appropriateness panel.Therapeutic advances in gastroenterology · 2024Article
- Vedolizumab Safety During Pregnancy and Lactation in a Patient with Ulcerative Colitis: A Case Report.Clinical and experimental gastroenterology · 2024Article
- Sexual and reproductive health considerations in the care of young adults with inflammatory bowel disease: A multidisciplinary conversation.Health care transitions · 2024Article
- Associations between sex hormones, receptors, binding proteins and inflammatory bowel disease: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Monitoring of Inflammatory Bowel Disease in Pregnancy: A Review of the Different Modalities.Journal of clinical medicine · 2023Review
- Patients' perspectives on, experience with and concerns about crohn's disease: insights from Chinese social media.BMC gastroenterology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory bowel disease (IBD) frequently affects women of childbearing age and can have implications in pregnancy. Most women with IBD have comparable fertility with women in the general population. Fertility is reduced in women with active disease or previous ileal-pouch-anal anastomosis (IPAA) surgery and is temporarily reduced in men taking sulfasalazine. Women with IBD have an increased risk of preterm delivery, low birth weight, small-for-gestational-age infants and Cesarean section (CS) delivery, however, no increased risk of congenital abnormalities. These adverse outcomes are particularly prevalent for women with active IBD compared with those with quiescent disease. Conception should occur during disease remission to optimize maternal and fetal outcomes and reduce the risk of disease exacerbations during pregnancy. Pre-conception counseling is therefore pertinent to provide patient education, medication review for risk of teratogenicity and objective disease assessment. Most medications are safe during pregnancy and breastfeeding, with the exception of methotrexate, ciclosporin, allopurinol and tofacitinib. Delivery modality should be guided by obstetric factors in most cases; however, CS is recommended for women with active perianal disease and can be considered for women with inactive perianal disease or IPAA. In conclusion, most women with IBD have uncomplicated pregnancies. Active IBD is the predominant predictor of poor outcomes and disease exacerbations; therefore, maintenance of disease remission during and before pregnancy is crucial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.