Evidence map›Paper›PMID 34046083›Full record

ArticleTherapeutic advances in gastroenterology2021

Biosimilar knowledge and viewpoints among Brazilian inflammatory bowel disease patients.

Karoline Soares Garcia, Bianca Pocopetz Facas, Marta Brenner Machado, Fábio Vieira Teixeira, Luisa Avedano, Sanna Lönnfors, Rogério Saad Hossne, Laurent Peyrin-Biroulet, Natália Sousa Freitas Queiroz

Open access · goldAbstract read
In one paragraph

Article in Therapeutic advances in gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Switching from Adalimumab Reference Product to and Among Adalimumab Biosimilars Outside the USA: Insights for US Clinicians.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Karoline Soares GarciaDepartment of Gastroenterology, University of São Paulo School of Medicine, 255 Doutor Enéas de Carvalho Aguiar Avenue, São Paulo, SP 05403000, Brazil.
Bianca Pocopetz FacasDepartment of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-9990-5093
Marta Brenner MachadoDepartment of Gastroenterology, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Brazilian Crohn's Disease and Ulcerative Colitis Association (Associação Brasileira de Colite Ulcerativa e Doença de Crohn: ABCD), Porto Alegre, Brazil.
Fábio Vieira TeixeiraGastrosaúde: IBD Clinic, Marília, SP, Brazil.
Luisa AvedanoEuropean Federation of Crohn's and Ulcerative Colitis Association (EFCCA), Brussels, Belgium, UK.
Sanna LönnforsEuropean Federation of Crohn's and Ulcerative Colitis Association (EFCCA), Brussels, Belgium, UK.
Rogério Saad HossnePaulista State University (UNESP): Botucatu Medical School, São Paulo, Brazil.
Laurent Peyrin-BirouletDepartment of Gastroenterology, Nancy University Hospital, Nancy, France.
Natália Sousa Freitas QueirozDepartment of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-2857-0825
Universidade de São Paulo · BRCrohn's and Colitis UK · GBCentre Hospitalier Régional et Universitaire de Nancy · FRFaculdade de Medicina de Marília · BRPontifícia Universidade Católica do Rio Grande do Sul · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this analysis we aimed to describe Brazilian inflammatory bowel disease (IBD) patients' knowledge and perceptions regarding biosimilars and compare with viewpoints from non-Brazilian patients.

methodsAn online survey consisting of 19 questions was made available by the European Federation of Crohn's and Ulcerative Colitis Associations between July 2018 and December 2018. Only respondents who had heard of biosimilars were asked to respond to all of the questions.

resultsA total of 102 Brazilian IBD patients responded to the survey. The majority (78.4%) of patients had been exposed to anti-tumor-necrosis-factor drugs and 63.4% of them had heard of biosimilars. Brazilian respondents worried significantly more about biosimilars being less effective than the originator (62.5%

conclusionsBrazilian patients reported higher rates of misconceptions regarding biosimilars than non-Brazilian IBD patients. Although patients still worry about different aspects regarding biosimilars, they also tend to be confident that biosimilars will have an impact on the management of their disease. With the recent approval of many biosimilars in Brazil and the imminent widespread use of these drugs, our data raise awareness for the need of providing patient education to prevent negative expectations toward switching to biosimilars.

Indexed as

adalimumabbiosimilarinflammatory bowel diseaseinfliximab

Identifiers

PMID34046083
PMCPMC8135202
OpenAlexW3162690879

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.