Evidence map›Paper›PMID 34046012›Full record

ArticleFrontiers in endocrinology2021

Thyroid Function Changes and Pubertal Progress in Females: A Longitudinal Study in Iodine-Sufficient Areas of East China.

Yingying Wang, Dandan He, Chaowei Fu, Xiaolian Dong, Feng Jiang, Meifang Su, Qian Xu, Peixin Huang, Na Wang, Yue Chen and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Yingying WangDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
Dandan HeDepartment of School Hygiene, Minhang District Center for Disease Control and Prevention, Shanghai, China.
Chaowei FuDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
Xiaolian DongDepartment of Chronic Disease Control and Prevention, Deqing County Center for Disease Control and Prevention, Huzhou, China.
Feng JiangDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
Meifang SuDepartment of Chronic Disease Control and Prevention, Yuhuan City Center for Disease Control and Prevention, Taizhou, China.
Qian XuDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
Peixin HuangDepartment of Chronic Disease Control and Prevention, Haimen City Center for Disease Control and Prevention, Nantong, China.
Na WangDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
Yue ChenSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Qingwu JiangDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
Fudan University · CNHainan Center for Disease Control & Prevention · CNShanghai Municipal Center For Disease Control Prevention · CNUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The onset of puberty is influenced by thyroid function, and thyroid hormones (THs) fluctuate substantially during the period of pubertal development. However, it needs to be further clarified how THs change at specific puberty stages and how it influences pubertal development in girls. So far, longitudinal data from China are scarce. Methods: A cohort study was conducted among girls during puberty in iodine-sufficient regions of East China between 2017 to 2019. Serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were determined for each participant. Thyroid homeostasis structure parameters (THSPs), including the ratio of FT4 to FT3 (FT4/FT3), Jostel's TSH index (TSHI), and thyroid feedback quantile-based index (TFQI), were calculated. Puberty category scores (PCS), calculated based on the Puberty Development Scale (PDS), was used to assess the stage of puberty. Girls were grouped into three categories according to PCS changes (△PCS) and six categories according puberty stage (B Results: The levels of serum TSH and FT3 decreased while serum FT4 increased during the study period (P<0.001). In multiple linear regression analyses, after adjustment for covariables, FT3 decreased by an additional 0.24 pmol/L (95% CI: -0.47 to -0.01) in the higher △PCS group than the lower △PCS group. Compared with the B Conclusions: Serum TSH and FT3 decreased while serum FT4 increased among girls during puberty. Both the initial stage and the velocity of pubertal development were related to thyroid hormone fluctuations.

Indexed as

Sodium Chloride, DietaryAdolescentChildChinaCohort StudiesFemaleHumansIodineLinear ModelsLongitudinal StudiesPubertyRegression AnalysisThyroid Function TestsThyroid GlandThyrotropinThyroxineIodineiodized saltSodium Chloride, DietaryThyrotropinThyroxineTriiodothyroninecohort studyfemaleiodine sufficient areapubertythyroid hormones

Identifiers

PMID34046012
PMCPMC8146907
OpenAlexW3162219808

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.