Evidence map›Paper›PMID 34046004›Full record

ArticleFrontiers in neurology2021

Reduction of Retinal Thickness Ipsilateral to Hippocampal Sclerosis in Epilepsy.

Weixi Xiong, Lu Lu, Qin Chen, Yingfeng Xiao, Dongmei An, Josemir W Sander, Ming Zhang, Dong Zhou

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07716930 (Retina-Based Biomarkers in Epilepsy), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07716930 enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Retina-Based Biomarkers in Epilepsy: Structural and Microvascular OCT Changes and Inflammatory Markers (sCD14, sCD163, CCL2, IL-1β) in Relation to Pathophysiology, Phenotype, Prognosis, and Drug-Resistant Epilepsy (DRE)

TypeobservationalSponsorKemal TutkavulRan2026 to 2028Enrolled250ConditionsEpilepsy (Treatment Refractory), Epilepsy
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Weixi XiongDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, China.
Lu LuDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, China.
Qin ChenDepartment of Ophthalmology, West China Hospital of Sichuan University, Chengdu, China.
Yingfeng XiaoDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, China.
Dongmei AnDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, China.
Josemir W SanderThe National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London Institute of Neurology, London, United Kingdom.
Ming ZhangDepartment of Ophthalmology, West China Hospital of Sichuan University, Chengdu, China.
Dong ZhouDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, China.
Sichuan University · CNWest China Hospital of Sichuan University · CNNational Institute for Health Research · GBShanghai Center for Brain Science and Brain-Inspired Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

adult with epilepsydrug resistant epilepsyoptical coherence tomographyretinal nerve fiber layertemporal lobe epilepsy

Identifiers

PMID34046004
PMCPMC8144461
OpenAlexW3160257585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.