Evidence map›Paper›PMID 34045955›Full record

ArticleFrontiers in pharmacology2021

Histamine can be Formed and Degraded in the Human and Mouse Heart.

Joachim Neumann, Juliane M Grobe, Jacqueline Weisgut, Hubert G Schwelberger, Wieslawa Agnieszka Fogel, Margaréta Marušáková, Hartmut Wache, Heike Bähre, Igor B Buchwalow, Stefan Dhein and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Temperature alters the inotropic and chronotropic effect of DNaunyn-Schmiedeberg's archives of pharmacology · 2025
    Article
  3. Article
  4. Stimulation of histamine HNaunyn-Schmiedeberg's archives of pharmacology · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Lysergic acid diethylamide stimulates cardiac human HNaunyn-Schmiedeberg's archives of pharmacology · 2024
    Article
  9. Clonidine stimulates force of contraction via histamine HNaunyn-Schmiedeberg's archives of pharmacology · 2024
    Article
  10. Review
  11. Ergometrine stimulates histamine HNaunyn-Schmiedeberg's archives of pharmacology · 2023
    Article
  12. Function and Role of Histamine HPharmaceuticals (Basel, Switzerland) · 2023
    Review
  13. Review
  14. Article
  15. Ergotamine Stimulates Human 5-HTInternational journal of molecular sciences · 2023
    Article
  16. Article
  17. The Roles of Cardiovascular HFrontiers in pharmacology · 2021
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Joachim NeumannInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.
Juliane M GrobeInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.
Jacqueline WeisgutInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.
Hubert G SchwelbergerDepartment of Visceral, Transplant and Thoracic Surgery, Molecular Biology Laboratory, Medical University Innsbruck, Innsbruck, Austria.
Wieslawa Agnieszka FogelDepartment of Hormone Biochemistry, Medical University of Lodz, Lodz, Poland.
Margaréta MarušákováInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.
Hartmut WacheInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.
Heike BähreResearch Core Unit Metabolomics and Institute of Pharmacology, Hannover Medical School, Hannover, Germany.
Igor B BuchwalowInstitute for Hematopathology, Hamburg, Germany.
Stefan DheinKlinik für Herzchirurgie, Herzzentrum der Universität Leipzig, Leipzig, Germany.
Britt HofmannDepartment of Cardiothoracic Surgery, Heart Centre of the University Clinics Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Uwe KirchheferInstitut für Pharmakologie und Toxikologie, Universitätsklinikum Münster, Westfälische Wilhelms-Universität, Münster, Germany.
Ulrich GergsInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.
Martin Luther University Halle-Wittenberg · DEInnsbruck Medical University · ATInstitut für Hämatopathologie Hamburg · DELeipzig University · DEMedical University of Lodz · PLMedizinische Hochschule Hannover · DEUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histamine is metabolized by several enzymes

Indexed as

chronotropyH2-histamine receptorhistamine synthesis and degradationhuman atriuminotropytransgenic mice

Identifiers

PMID34045955
PMCPMC8144513
OpenAlexW3160637687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.