Evidence map›Paper›PMID 34045924›Full record

ReviewCurrent genomics2021

The Journey from Two-Step to Multi-Step Phosphorelay Signaling Systems.

Deepti Singh, Priyanka Gupta, Sneh Lata Singla-Pareek, Kadambot H M Siddique, Ashwani Pareek

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Engineering signalling pathways in mammalian cells.Nature biomedical engineering · 2024
    Review
  5. Article
  6. Review
  7. Review
  8. Oxidative stress response pathways in fungi.Cellular and molecular life sciences : CMLS · 2022
    Review
  9. Frontiers in microbiology · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Deepti Singh1Stress Physiology and Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India; 2Plant Stress Biology, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India; 3The UWA Institute of Agriculture, The University of Western Australia, Perth WA 6001, Australia; 4National Agri-Food Biotechnology Institute, Punjab, Ajitgarh 140306, India.
Priyanka Gupta1Stress Physiology and Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India; 2Plant Stress Biology, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India; 3The UWA Institute of Agriculture, The University of Western Australia, Perth WA 6001, Australia; 4National Agri-Food Biotechnology Institute, Punjab, Ajitgarh 140306, India.
Sneh Lata Singla-Pareek1Stress Physiology and Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India; 2Plant Stress Biology, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India; 3The UWA Institute of Agriculture, The University of Western Australia, Perth WA 6001, Australia; 4National Agri-Food Biotechnology Institute, Punjab, Ajitgarh 140306, India.
Kadambot H M Siddique1Stress Physiology and Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India; 2Plant Stress Biology, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India; 3The UWA Institute of Agriculture, The University of Western Australia, Perth WA 6001, Australia; 4National Agri-Food Biotechnology Institute, Punjab, Ajitgarh 140306, India.
Ashwani Pareek1Stress Physiology and Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India; 2Plant Stress Biology, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India; 3The UWA Institute of Agriculture, The University of Western Australia, Perth WA 6001, Australia; 4National Agri-Food Biotechnology Institute, Punjab, Ajitgarh 140306, India.
Jawaharlal Nehru University · INInternational Centre for Genetic Engineering and Biotechnology · INThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe two-component signaling (TCS) system is an important signal transduction machinery in prokaryotes and eukaryotes, excluding animals, that uses a protein phosphorylation mechanism for signal transmission.

conclusionProkaryotes have a primitive type of TCS machinery, which mainly comprises a membrane-bound sensory histidine kinase (HK) and its cognate cytoplasmic response regulator (RR). Hence, it is sometimes referred to as two-step phosphorelay (TSP). Eukaryotes have more sophisticated signaling machinery, with an extra component - a histidine-containing phosphotransfer (HPT) protein that shuttles between HK and RR to communicate signal baggage. As a result, the TSP has evolved from a two-step phosphorelay (His-Asp) in simple prokaryotes to a multi-step phosphorelay (MSP) cascade (His-Asp-His-Asp) in complex eukaryotic organisms, such as plants, to mediate the signaling network. This molecular evolution is also reflected in the form of considerable structural modifications in the domain architecture of the individual components of the TCS system. In this review, we present TCS system's evolutionary journey from the primitive TSP to advanced MSP type across the genera. This information will be highly useful in designing the future strategies of crop improvement based on the individual members of the TCS machinery.

Indexed as

histidine-containing phosphotransfer proteinshistidine kinasesmulti-step phosphorelayresponse regulatorsTwo-component systemtwo-step phosphorelay

Identifiers

PMID34045924
PMCPMC8142344
OpenAlexW3118662821

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.