Evidence map›Paper›PMID 34045886›Full record

ArticlePharmacogenomics and personalized medicine2021

Trigger-Specific Remodeling of K

Ann-Kathrin Rahm, Dominik Gramlich, Teresa Wieder, Mara Elena Müller, Axel Schoeffel, Fadwa A El Tahry, Patrick Most, Tanja Heimberger, Steffi Sandke, Tanja Weis and 5 more

Open access · goldAbstract read
In one paragraph

Article in Pharmacogenomics and personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Genome and atrial fibrillation.Journal of arrhythmia · 2023
    Review
  8. Enhanced CaCirculation research · 2023
    Article
  9. Emerging Antiarrhythmic Drugs for Atrial Fibrillation.International journal of molecular sciences · 2022
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Ann-Kathrin RahmDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg, 69120, Germany.
Dominik GramlichDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg, 69120, Germany.ORCID 0000-0003-1050-9030
Teresa WiederDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg, 69120, Germany.
Mara Elena MüllerDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg, 69120, Germany.ORCID 0000-0003-2455-9880
Axel SchoeffelDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg, 69120, Germany.
Fadwa A El TahryDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg, 69120, Germany.
Patrick MostDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg, 69120, Germany.
Tanja HeimbergerDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg, 69120, Germany.
Steffi SandkeDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg, 69120, Germany.
Tanja WeisDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg, 69120, Germany.
Nina D UllrichInstitute of Physiology and Pathophysiology, Department of Cardiovascular Physiology, Heidelberg University, Heidelberg, 69120, Germany.ORCID 0000-0002-1077-3125
Thomas KorffInstitute of Physiology and Pathophysiology, Department of Cardiovascular Physiology, Heidelberg University, Heidelberg, 69120, Germany.
Patrick LugenbielDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg, 69120, Germany.
Hugo A KatusDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg, 69120, Germany.
Dierk ThomasDepartment of Cardiology, Medical University Hospital Heidelberg, Heidelberg, 69120, Germany.ORCID 0000-0002-5687-7843
Heidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimEffective antiarrhythmic treatment of atrial fibrillation (AF) constitutes a major challenge, in particular, when concomitant heart failure (HF) is present. HF-associated atrial arrhythmogenesis is distinctly characterized by prolonged atrial refractoriness. Small-conductance, calcium-activated K

methods

resultsAtrial

conclusionReduction of K

Indexed as

atrial fibrillationcalciumKCa channelKCNNremodelingSK channel

Identifiers

PMID34045886
PMCPMC8144362
OpenAlexW3163532320

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.