Observational studyInternational journal of chronic obstructive pulmonary disease
Physical Frailty in COPD Patients with Chronic Respiratory Failure.
Observational study in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05491876 (Comparison Of Active Cycle Of Breathing Technique And Breathing Exercises On Oxygen Saturation And Pulmonary Function Test In Post ICU COVID-19 Patients), which is not on this map. Cited by 18 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison Of Active Cycle Of Breathing Technique And Breathing Exercises On Oxygen Saturation And Pulmonary Function Test In Post ICU COVID-19 Patients
Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- The impact of frailty on clinical outcomes among individuals with COPD: a systematic review and meta-analysis.BMC pulmonary medicine · 2025Pooled it
- Frailty in COPD: Clinical Impact, Diagnosis, Biomarkers, and Management Strategies.International journal of chronic obstructive pulmonary disease · 2025Pooled it
- Frailty and its influence on mortality and morbidity in COPD: A Systematic Review and Meta-Analysis.Internal and emergency medicine · 2023Pooled it
- Prevalence and risk factors of frailty in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis.European geriatric medicine · 2023Pooled it
- Prevalence and clinical impact of frailty in COPD: a systematic review and meta-analysis.BMC pulmonary medicine · 2023Pooled it
- The Effects of Aerobic Exercise on Prognosis, Quality of Life, and Psychological Outcomes of Patients With Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026Article
- Frailty in older adults with chronic obstructive pulmonary disease: preliminary findings of prevalence and care priorities.BMC geriatrics · 2025Article
- Prevalence, Persistence, and Agreement of Physical Frailty Tools in Patients with Severe COPD Declining Pulmonary Rehabilitation: An Exploratory 1-Year Prospective Cohort Study.Journal of clinical medicine · 2025Article
- Association Between the Non-High-Density Lipoprotein Cholesterol-to-High-Density Lipoprotein Cholesterol Ratio (NHHR) and Mortality in Patients with COPD: Evidence From the NHANES 1999-2018.International journal of chronic obstructive pulmonary disease · 2025Article
- The implications of frailty in older adults with epilepsy.Epilepsia open · 2024Review
- Fall Risk and Medication Use Near End of Life Among Adults With Chronic Obstructive Pulmonary Disease.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
- Impact of Frailty on Symptom Burden in Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2024Review
- Functional clinical impairments and frailty in interstitial lung disease patients.ERJ open research · 2022Article
- High-Density Lipoproteins: A Role in Inflammation in COPD.International journal of molecular sciences · 2022Review
- Role of Short-Chain Fatty Acids Produced by Gut Microbiota in Innate Lung Immunity and Pathogenesis of the Heterogeneous Course of Chronic Obstructive Pulmonary Disease.International journal of molecular sciences · 2022Review
- Home-based Pulmonary Rehabilitation is Effective in Frail COPD Patients with Chronic Respiratory Failure.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2022Article
- Non-pharmacological Management in Palliative Care for Patients With Advanced COPD.Frontiers in cardiovascular medicine · 2022Review
- Longer daily oxygen use associates with more adverse events, symptoms, and worse health status in long-term oxygen therapy.Chronic respiratory diseaseArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of physical frailty and its clinical characteristics in advanced chronic obstructive pulmonary disease (COPD) is unknown, as well as the usefulness of functional capacity tests to screen for physical frailty. The aim of the study was to evaluate the proportion and clinical portrait of COPD patients with chronic respiratory failure exhibiting physical frailty at the time of referral to home-based pulmonary rehabilitation. We also evaluate the usefulness of the short physical performance battery (SPPB) and timed-up and go (TUG) as potential screening tools for physical frailty. Finally, we evaluated the specific contribution of gait speed to the frailty Fried total score.
methodsThis was a prospective observational study in which physical frailty was defined using Fried criteria (body mass loss, exhaustion, low physical activity, slower walking and weakness). Clinical portrait was documented from daily physical activity, exercise tolerance, functional capacity, anxiety and depressive symptoms, health-related quality of life, and fatigue scores. The ability of the SPPB and TUG to predict physical frailty was investigated using receiver operating characteristic curves. Contribution of each Fried criteria was evaluated with a principal component analysis (PCA).
resultsAmongst the 44 included participants (FEV
conclusionPhysical frailty affects a large proportion of COPD patients with chronic respiratory failure starting a home-based intervention and was associated with worse clinical status. Although the present results need to be confirmed by adequately powered studies, gait speed seems to have the potential to become a simple screening tool for physical frailty in this population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.