Evidence map›Paper›PMID 34045776›Full record

ArticleJournal of physics D: Applied physics2017

Conducting polymer nanowires for control of local protein concentration in solution.

Joshua D Morris, Scott B Thourson, Krishna Panta, Bret N Flanders, Christine K Payne

Open access · greenAbstract read
In one paragraph

Article in Journal of physics D: Applied physics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Joshua D MorrisSchool of Science and Technology, Georgia Gwinnett College, Lawrenceville, GA 30043, USA.
Scott B ThoursonGeorge W. Woodruff School of Mechanical Engineering (BioEngineering Graduate Program), Georgia Institute of Technology, Atlanta, GA 30332, USA.
Krishna PantaDepartment of Physics, Kansas State University, Manhattan, KS 66506, USA.
Bret N FlandersDepartment of Physics, Kansas State University, Manhattan, KS 66506, USA.
Christine K PayneSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Georgia Institute of Technology · USKansas State University · USGeorgia Gwinnett College · US

Funding

Conducting polymer nanowires for neural modulationR21EY026392 · NEI · GEORGIA INSTITUTE OF TECHNOLOGY · PI PAYNE, CHRISTINE K · 2015 to 2017
$453k
NEI NIH HHS R21 EY026392
6 · The paper itself

Abstract

Interfacing devices with cells and tissues requires new nanoscale tools that are both flexible and electrically active. We demonstrate the use of PEDOT:PSS conducting polymer nanowires for the local control of protein concentration in water and biological media. We use fluorescence microscopy to compare the localization of serum albumin in response to electric fields generated by narrow (760 nm) and wide (1.5 μm) nanowires. We show that proteins in deionized water can be manipulated over a surprisingly large micron length scale and that this distance is a function of nanowire diameter. In addition, white noise can be introduced during the electrochemical synthesis of the nanowire to induce branches into the nanowire allowing a single device to control multiple nanowires. An analysis of growth speed and current density suggests that branching is due to the Mullins-Sekerka instability, ultimately controlled by the roughness of the nanowire surface. These small, flexible, conductive, and biologically compatible PEDOT:PSS nanowires provide a new tool for the electrical control of biological systems.

Identifiers

PMID34045776
PMCPMC8153065
OpenAlexW2603601763

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.