Evidence map›Paper›PMID 34045771›Full record

ArticleIsrael journal of chemistry2019

Protein Interactions with Nanoparticle Surfaces: Highlighting Solution NMR Techniques.

Y Randika Perera, Rebecca A Hill, Nicholas C Fitzkee

Abstract read
In one paragraph

Article in Israel journal of chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
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  14. DiffusionNano letters · 2022
    Article
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Y Randika PereraDepartment of Chemistry, Mississippi State University, Mississippi State, MS 39762, USA.
Rebecca A HillDepartment of Chemistry, Mississippi State University, Mississippi State, MS 39762, USA.
Nicholas C FitzkeeDepartment of Chemistry, Mississippi State University, Mississippi State, MS 39762, USA.

Funding

Structure, Orientation, and Competitive Interactions of S. Epidermidis Biofilm Proteins on SurfacesR01AI139479 · NIAID · MISSISSIPPI STATE UNIVERSITY · PI FITZKEE, NICHOLAS C · 2018 to 2022
$1.8M
NIAID NIH HHS R01 AI139479
6 · The paper itself

Abstract

In the last decade, nanoparticles (NPs) have become a key tool in medicine and biotechnology as drug delivery systems, biosensors and diagnostic devices. The composition and surface chemistry of NPs vary based on the materials used: typically organic polymers, inorganic materials, or lipids. Nanoparticle classes can be further divided into sub-categories depending on the surface modification and functionalization. These surface properties matter when NPs are introduced into a physiological environment, as they will influence how nucleic acids, lipids, and proteins will interact with the NP surface. While small-molecule interactions are easily probed using NMR spectroscopy, studying protein-NP interactions using NMR introduces several challenges. For example, globular proteins may have a perturbed conformation when attached to a foreign surface, and the size of NP-protein conjugates can lead to excessive line broadening. Many of these challenges have been addressed, and NMR spectroscopy is becoming a mature technique for

Indexed as

NMR relaxationProtein surface interactionssurface structure, biomolecular corona

Identifiers

PMID34045771
PMCPMC8152826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.