ArticleNature metabolism2021
Human plasma proteomic profiles indicative of cardiorespiratory fitness.
Erratum issued Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Nature metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06247774 (Reducing Heart Failure Risk in Late-Life With Physical Activity), which is not on this map. Cited by 49 papers.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
11.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reducing Heart Failure Risk in Late-Life With Physical Activity: Impact on Cardiac Structure and Function and Proteomic Signatures
Who cites it
49 citing papers in PubMed, 86 citations in OpenAlex.
- Circulating Proteomics Identifies a Dynamic Profile of Hepatic Steatosis During Metabolic Intervention.Journal of the American Heart Association · 2025Trial
- Novel whole blood transcriptome signatures of changes in maximal aerobic capacity in response to endurance exercise training in healthy women.Physiological genomics · 2023Trial
- Explainable Plasma Proteomics-Based Machine Learning for Osteoporosis Diagnosis, Prognosis, and Protein Biomarker Discovery in the UK Biobank.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Multi-omics signatures of circulating factors associated with cardiorespiratory fitness adaptations in individuals with prediabetes.Cardiovascular diabetology · 2026Article
- Plasma Proteomic Signatures of Physical Activity Provide Insights into Biological Impacts and its Protective Role against Dementia.Medicine and science in sports and exercise · 2026Observational
- An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease.Aging cell · 2026Article
- Blood Biochemical Responses to Acute Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC).bioRxiv : the preprint server for biology · 2026Article
- Integration of multiomic and multi-phenotypic data identifies biological pathways associated with physical fitness.Communications biology · 2026Article
- Plasma proteome mediates the associations between air pollution exposure and disease risk.Nature communications · 2026Article
- Acute exercise rewires the proteomic landscape of human immune cells.Nature communications · 2026Article
- Temporal Dynamics of the Plasma Proteomic Landscape Reveals Maladaptation in ME/CFS Following Exertion.Molecular & cellular proteomics : MCP · 2025Article
- Serum Metabolomics Reveals Metabolic Changes in Freestyle Wrestlers During Different Training Stages.Metabolites · 2025Article
- Article
- Plasma proteomic profiles reveal proteins and three characteristic patterns associated with osteoporosis: A prospective cohort study.Journal of advanced research · 2025Article
- Epidemiology and Cardiovascular Benefits of Physical Activity and Exercise.Circulation research · 2025Review
- Next-Generation Approaches in Sports Medicine: The Role of Genetics, Omics, and Digital Health in Optimizing Athlete Performance and Longevity-A Narrative Review.Life (Basel, Switzerland) · 2025Review
- Prospective Investigation Unravels Plasma Proteomic Links to Dementia.Molecular neurobiology · 2025Article
- The Metabolic Signature of Cardiorespiratory Fitness.Scandinavian journal of medicine & science in sports · 2025Article
- Clusters of multidimensional exercise response patterns and estimated heart failure risk in the Framingham Heart Study.ESC heart failure · 2024Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
19 authors at 8 institutions in 5 countries.
Jeremy M RobbinsDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9672-4841
Bennet PetersonCardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7906-5146
Daniela SchrannerCardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2316-318X
Usman A TahirDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3657-6082
Theresa RienmüllerInstitute of Health Care Engineering with Testing Center of Medical Devices, Graz University of Technology, Graz, Austria.ORCID http://orcid.org/0000-0002-9623-106X
Shuliang DengCardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Michelle J KeyesCardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0303-1390
Daniel H KatzDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7237-8502
Pierre M Jean BeltranBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5106-0992
Jacob L BarberDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Christian BaumgartnerInstitute of Health Care Engineering with Testing Center of Medical Devices, Graz University of Technology, Graz, Austria.
Steven A CarrBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Sujoy GhoshCardiovascular & Metabolic Disorders Program and Center for Computational Biology, Duke-NUS Graduate Medical School, Singapore, Singapore.
Changyu ShenCardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Lori L JenningsNovartis Institutes for Biomedical Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5130-8417
Robert RossSchool of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.ORCID http://orcid.org/0000-0001-6875-785X
Mark A SarzynskiDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.ORCID http://orcid.org/0000-0001-6705-0668
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.ORCID http://orcid.org/0000-0002-0048-491X
Robert E GersztenDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. rgerszte@bidmc.harvard.edu.ORCID http://orcid.org/0000-0002-6767-7687
Beth Israel Deaconess Medical Center · USBroad Institute · USGraz University of Technology · ATUniversity of South Carolina · USDuke-NUS Medical School · SGNovartis (United States) · USPennington Biomedical Research Center · USQueen's University · CA
Funding
Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Leigh Lamonica · 2012 to 2026
$69.1MROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6MA Biochemical Roadmap of Exercise Signaling - Pilot Project for MoTrPAC ConsortiumU24DK112340 · NIDDK · BROAD INSTITUTE, INC. · PI STEVEN A CARR, Clary B Clish · 2017 to 2026
$16.2MHERITAGE STUDY: GENETICS, EXERCISE &RISK FACTORSR01HL045670 · NHLBI · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI RANKINEN, TUOMO · 1992 to 2010
$6.8MProteomics of Cardiometabolic and Renal Traits in African AmericansR01HL133870 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROBERT E GERSZTEN · 2017 to 2026
$6.7MTransgenics CoreP30GM118430 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI GETTYS, THOMAS W · 2016 to 2020
$5.8MMolecular Basis of Exercise-induced Changes in HDL FunctionR01HL146462 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SARZYNSKI, MARK ANDREW · 2019 to 2023
$3.6MProteomic Pathway Discovery in Cardiovascular DiseaseR01HL132320 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GERSZTEN, ROBERT E, RAMACHANDRAN, VASAN S · 2016 to 2019
$3.4MBiochemical profiling to identify cardiometabolic responsiveness to an endurance exercise interventionR01NR019628 · NINR · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GERSZTEN, ROBERT E, SARZYNSKI, MARK ANDREW · 2021 to 2025
$2.7MHERITAGE STUDY: GENETICS, EXERCISE &RISK FACTORSR01HL047317 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 1992 to 2003
$1.8MDMGV and the AGXT2 pathway in chronic exercise-induced cardiometabolic adaptations.K23HL150327 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROBBINS, JEREMY · 2020 to 2024
$850kHERITAGE STUDY: GENETICS, EXERCISE &RISK FACTORSR01HL047327 · NHLBI · INDIANA UNIVERSITY BLOOMINGTON · PI SKINNER, JAMES STANFORD · 1992 to 2003
$106kNHLBI NIH HHS K23 HL150327NHLBI NIH HHS R01 HL045670NHLBI NIH HHS R01 HL047317NHLBI NIH HHS R01 HL047323NHLBI NIH HHS R01 HL047327NHLBI NIH HHS R01 HL132320NHLBI NIH HHS R01 HL133870NHLBI NIH HHS R01 HL146462NIDDK NIH HHS P30 DK040561NIDDK NIH HHS U24 DK112340NIGMS NIH HHS P30 GM118430NIGMS NIH HHS U54 GM104940NINR NIH HHS R01 NR019628
Abstract
Maximal oxygen uptake (VO
Indexed as
Blood ProteinsCardiorespiratory FitnessProteomeProteomicsBiomarkersExerciseHumansLife StyleMetabolic Networks and PathwaysOxygen ConsumptionBiomarkersBlood ProteinsProteome
Identifiers
What OpenQuestion holds
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Registered trials
NCT06247774ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.