ArticleNature microbiology2021
A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants.
Open access · bronzeAbstract read
In one paragraph
Article in Nature microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
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- The intestinal environment potentiates bacteriophage adaptation in response to phenotypic resistance inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Enhancing phage therapy by coating single bacteriophage-infected bacteria with polymer to preserve phage vitality.Nature biomedical engineering · 2025Article
- Aromatics from fossil fuels and breast cancer.iScience · 2025Review
- Vaccine-enhanced competition permits rational bacterial strain replacement in the gut.Science (New York, N.Y.) · 2025Article
- Context-dependent change in the fitness effect of (in)organic phosphate antiporter glpT during Salmonella Typhimurium infection.Nature communications · 2025Article
- 100+ years of phase variation: the premier bacterial bet-hedging phenomenon.Microbiology (Reading, England) · 2025Review
- Mechanisms conferring multi-layered protection against intestinal Salmonella Typhimurium infection.FEMS microbiology reviews · 2025Review
- Diagnosing and engineering gut microbiomes.EMBO molecular medicine · 2024Review
- Evaluation of a FlpA Glycoconjugate Vaccine with TenVaccines · 2024Article
- From microbiome composition to functional engineering, one step at a time.Microbiology and molecular biology reviews : MMBR · 2023Review
- Microbiome-liver crosstalk: A multihit therapeutic target for liver disease.World journal of gastroenterology · 2023Review
- Flagellar-based motility accelerates IgA-mediated agglutination ofFrontiers in immunology · 2023Article
- Article
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Corrections and comments
- Commented on by
Authors and funding
29 authors at 11 institutions in 5 countries.
Médéric Diard *Biozentrum, University of Basel, Basel, Switzerland. mederic.diard@unibas.ch.ORCID http://orcid.org/0000-0001-5914-8059
Erik BakkerenInstitute of Microbiology, Department of Biology, ETH Zürich, Zürich, Switzerland.
Verena LentschInstitute of Food, Nutrition and Health, D-HEST, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0001-7440-4604
Andrea RockerBiozentrum, University of Basel, Basel, Switzerland.
Nahimi Amare BekeleBiozentrum, University of Basel, Basel, Switzerland.
Daniel HocesInstitute of Food, Nutrition and Health, D-HEST, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-1451-5166
Selma AslaniInstitute of Food, Nutrition and Health, D-HEST, ETH Zürich, Zürich, Switzerland.
Markus ArnoldiniInstitute of Food, Nutrition and Health, D-HEST, ETH Zürich, Zürich, Switzerland.
Flurina BöhiInstitute of Microbiology, Department of Biology, ETH Zürich, Zürich, Switzerland.
Kathrin Schumann-MoorInstitute of Microbiology, Department of Biology, ETH Zürich, Zürich, Switzerland.
Jozef AdamcikInstitute of Food, Nutrition and Health, D-HEST, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-4545-3826
Luca PiccoliInstitute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland.
Antonio LanzavecchiaInstitute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland.ORCID http://orcid.org/0000-0002-3041-7240
Beth M StadtmuellerDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Nicholas DonohueYork Biomedical Research Institute, Hull York Medical School, University of York, York, UK.ORCID http://orcid.org/0000-0002-0055-640X
Marjan W van der WoudeYork Biomedical Research Institute, Hull York Medical School, University of York, York, UK.ORCID http://orcid.org/0000-0002-0446-8829
Alyson HockenberryDepartment of Environmental Microbiology, Eawag, Dubendorf, Switzerland.
Patrick H ViollierMicrobiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-5249-9910
Laurent FalquetDepartment of Biology, University of Fribourg, Fribourg, Switzerland.ORCID http://orcid.org/0000-0001-8102-7579
Daniel WüthrichInfection Biology, University Hospital of Basel, Basel, Switzerland.
Ferdinando BonfiglioDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Claude LoverdoDepartment of Materials, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-0888-1717
Adrian EgliInfection Biology, University Hospital of Basel, Basel, Switzerland.
Giorgia ZandomeneghiInstitute for Physical Chemistry, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0001-9452-8751
Raffaele MezzengaInstitute of Food, Nutrition and Health, D-HEST, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-5739-2610
Otto HolstForschungszentrum Borstel, Borstel, Germany.
Beat H MeierInstitute for Physical Chemistry, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-9107-4464
Wolf-Dietrich Hardt *Institute of Microbiology, Department of Biology, ETH Zürich, Zürich, Switzerland. wolf-dietrich.hardt@micro.biol.ethz.ch.ORCID http://orcid.org/0000-0002-9892-6420
Emma Slack *Institute of Microbiology, Department of Biology, ETH Zürich, Zürich, Switzerland. emma.slack@hest.ethz.ch.ORCID http://orcid.org/0000-0002-2473-1145
ETH Zurich · CHUniversity of Basel · CHUniversità della Svizzera italiana · CHMedical University of Graz · ATResearch Center Borstel - Leibniz Lung Center · DESIB Swiss Institute of Bioinformatics · CHUniversity Hospital of Basel · CHUniversity of Geneva · CHUniversity of Illinois Urbana-Champaign · USUniversity of York · GBUniversity of Zurich · CH
Funding
NEONATAL FC RECEPTOR/IGG INTERACTIONR01AI041239 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BJORKMAN, PAMELA J · 1997 to 2018
$2.3MEuropean Research Council 865730NIAID NIH HHS R01 AI041239
Abstract
The ability of gut bacterial pathogens to escape immunity by antigenic variation-particularly via changes to surface-exposed antigens-is a major barrier to immune clearance
Indexed as
Administration, OralAnimalsAntibodies, BacterialAntigenic VariationBacterial ProteinsEvolution, MolecularGenetic FitnessHexosyltransferasesImmune EvasionImmunity, MucosalImmunoglobulin AIntestinesMiceMutationO AntigensSalmonella InfectionsAntibodies, BacterialBacterial ProteinsHexosyltransferasesImmunoglobulin AO-antigen polymeraseO AntigensSalmonella VaccinesVaccines, Attenuated
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.