ArticleCommunications biology2021
Ultra-deep sequencing reveals dramatic alteration of organellar genomes in Physcomitrella patens due to biased asymmetric recombination.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 28 citations in OpenAlex.
- Organelle genome evolution in the early-diverging brown algal lineage, Ishigeales.Journal of phycology · 2026Article
- The complete mitochondrial genome of Prinsepia uniflora (Rosaceae): De novo assembly, characterization, and phylogenetic analysis.BMC genomics · 2026Article
- Comparative mitochondrial genomics of cultivatedFrontiers in plant science · 2026Article
- Complete mitochondrial genome ofFrontiers in plant science · 2026Article
- Pan-mitogenome in Dipterocarpoideae: mitochondrial plastid DNAs and repeats shape the dynamic evolution of mitogenomes.BMC plant biology · 2025Article
- Mitochondrial genome structural variants and candidate cytoplasmic male sterility-related gene in sugarcane.BMC genomics · 2025Article
- Unraveling the mitochondrial genome ofFrontiers in plant science · 2025Article
- The complete mitochondrial genome assembly of Capsicum pubescens reveals key evolutionary characteristics of mitochondrial genes of two Capsicum subspecies.BMC genomics · 2024Article
- The complete mitochondrial genome of Castanopsis carlesii and Castanea henryi reveals the rearrangement and size differences of mitochondrial DNA molecules.BMC plant biology · 2024Article
- Assembly and comparative analysis of the complete mitochondrial genome of Fritillaria ussuriensis Maxim. (Liliales: Liliaceae), an endangered medicinal plant.BMC genomics · 2024Article
- De novo assembly of the complete mitochondrial genome of pepino (Solanum muricatum) using PacBio HiFi sequencing: insights into structure, phylogenetic implications, and RNA editing.BMC plant biology · 2024Article
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- Origin of minicircular mitochondrial genomes in red algae.Nature communications · 2023Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Destabilization of organelle genomes causes organelle dysfunction that appears as abnormal growth in plants and diseases in human. In plants, loss of the bacterial-type homologous recombination repair (HRR) factors RECA and RECG induces organelle genome instability. In this study, we show the landscape of organelle genome instability in Physcomitrella patens HRR knockout mutants by deep sequencing in combination with informatics approaches. Genome-wide maps of rearrangement positions in the organelle genomes, which exhibited prominent mutant-specific patterns, were highly biased in terms of direction and location and often associated with dramatic variation in read depth. The rearrangements were location-dependent and mostly derived from the asymmetric products of microhomology-mediated recombination. Our results provide an overall picture of organelle-specific gross genomic rearrangements in the HRR mutants, and suggest that chloroplasts and mitochondria share common mechanisms for replication-related rearrangements.
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