ArticleScientific reports2021
A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Meta-analysis of molecular imaging of translocator protein in major depression.Frontiers in molecular neuroscience · 2022Pooled it
- The impact of high-sugar diets on central nervous system disorders: mechanisms, pathogenesis, and dietary implication.Annals of medicine · 2025Review
- Acipimox as a potential antioxidant and neuromodulator mitigates high fat diet induced cognitive dysfunction.Scientific reports · 2025Article
- Deciphering the association between morphological differences in hypothalamic subregions and circulating ghrelin and leptin concentrations: exploratory evidence in anorexia nervosa and obesity.Translational psychiatry · 2025Article
- Cardiovascular Effects of Sucrose in Experimental Animals and Humans.Hypertension (Dallas, Tex. : 1979) · 2025Review
- Metabolomics reveals soluble epoxide hydrolase as a therapeutic target for high-sucrose diet-mediated gut barrier dysfunction.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- 4R-cembranoid suppresses glial cells inflammatory phenotypes and prevents hippocampal neuronal loss in LPS-treated mice.Journal of neuroscience research · 2024Article
- [Biomolecules · 2023Article
- High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight.International journal of obesity (2005) · 2023Article
- Cannabidiol ameliorates the anxiogenic and compulsive-like behaviors induced by chronic consumption of a high-carbohydrate diet in male mice.Metabolic brain disease · 2022Article
- Brain sex-dependent alterations after prolonged high fat diet exposure in mice.Communications biology · 2022Article
- [Research Progress in High-Sugar Diet and Inflammatory Diseases].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Review
- A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling.Development (Cambridge, England) · 2022Article
- Dietary fat: a potent microglial influencer.Trends in endocrinology and metabolism: TEM · 2022Review
- Astrocytes profiling in acute hepatic encephalopathy: Possible enrolling of glial fibrillary acidic protein, tumor necrosis factor-alpha, inwardly rectifying potassium channel (Kir 4.1) and aquaporin-4 in rat cerebral cortex.Frontiers in cellular neuroscience · 2022Article
- Hypothalamic inflammation in metabolic disorders and aging.Cellular and molecular life sciences : CMLS · 2021Review
- A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites.Microbiome · 2021Article
- Review
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the dire cardiometabolic consequences of the hypercaloric modern 'Western' diet are well known, there is not much information on the health impact of a high sucrose diet not inducing weight gain. Here, we tested the hypothesis that rats reared with intermittent binge access to sucrose in addition to normal chow would develop an inflammatory response in brain. To test this hypothesis, we undertook serial PET/MRI scans with the TSPO ligand [
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Registered trials
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