Evidence map›Paper›PMID 34045491›Full record

ArticleScientific reports2021

Predicting youth diabetes risk using NHANES data and machine learning.

Nita Vangeepuram, Bian Liu, Po-Hsiang Chiu, Linhua Wang, Gaurav Pandey

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Biological and Social Risk Factors for Predicting Type 2 Diabetes in Youth with Prediabetes: Review of Existing Prediction Models.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026
    Review
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  10. Supervised Machine Learning-Based Models for Predicting Raised Blood Sugar.International journal of environmental research and public health · 2024
    Article
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nita VangeepuramDivision of General Pediatrics, Department of Pediatrics, Icahn School of Medicine At Mount Sinai, 1 Gustave L. Levy Place Box 1077, New York, NY, 10029, USA. nita.vangeepuram@mssm.edu.ORCID 0000-0003-4848-4633
Bian LiuDepartment of Population Health Science and Policy, Icahn School of Medicine At Mount Sinai, New York, NY, USA.
Po-Hsiang ChiuDepartment of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine At Mount Sinai, New York, NY, USA.
Linhua WangDepartment of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine At Mount Sinai, New York, NY, USA.
Gaurav PandeyDepartment of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine At Mount Sinai, New York, NY, USA.

Funding

The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Maria Jose Rosa · 2014 to 2026
$21.3M
New York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
Boosting the Translational Impact of Scientific Competitions by Ensemble LearningR01GM114434 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PANDEY, GAURAV · 2015 to 2017
$1.3M
NIDDK NIH HHS P30 DK111022NIEHS NIH HHS P30 ES023515NIGMS NIH HHS R01 GM114434NIH HHS S10 OD026880
6 · The paper itself

Abstract

Prediabetes and diabetes mellitus (preDM/DM) have become alarmingly prevalent among youth in recent years. However, simple questionnaire-based screening tools to reliably assess diabetes risk are only available for adults, not youth. As a first step in developing such a tool, we used a large-scale dataset from the National Health and Nutritional Examination Survey (NHANES) to examine the performance of a published pediatric clinical screening guideline in identifying youth with preDM/DM based on American Diabetes Association diagnostic biomarkers. We assessed the agreement between the clinical guideline and biomarker criteria using established evaluation measures (sensitivity, specificity, positive/negative predictive value, F-measure for the positive/negative preDM/DM classes, and Kappa). We also compared the performance of the guideline to those of machine learning (ML) based preDM/DM classifiers derived from the NHANES dataset. Approximately 29% of the 2858 youth in our study population had preDM/DM based on biomarker criteria. The clinical guideline had a sensitivity of 43.1% and specificity of 67.6%, positive/negative predictive values of 35.2%/74.5%, positive/negative F-measures of 38.8%/70.9%, and Kappa of 0.1 (95%CI: 0.06-0.14). The performance of the guideline varied across demographic subgroups. Some ML-based classifiers performed comparably to or better than the screening guideline, especially in identifying preDM/DM youth (p = 5.23 × 10

Indexed as

Machine LearningAdolescentBlood GlucoseChildDiabetes Mellitus, Type 2FemaleHumansMaleMass ScreeningNutrition SurveysPrediabetic StateRisk AssessmentRisk FactorsSensitivity and SpecificityYoung AdultBlood Glucose

Identifiers

PMID34045491
PMCPMC8160335

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.